Literature summary for 3.4.24.23 extracted from

Welch, A.R.; Holman, C.M.; Browner, M.F.; Gehring, M.R.; Kan, C.C.; van Wart, H.E.
Purification of human matrilysin produced in Escherichia coli and characterization using a new optimized fluorogenic peptide substrate (1995), Arch. Biochem. Biophys., 324, 59-64.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens
-	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.026	-	2,4-Dinitrophenyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser	-	Homo sapiens
0.065	-	2,4-dinitrophenyl-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	expression in Escherichia coli	-
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2,4-Dinitrophenyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser + H2O	optimized fluorogenic substrate	Homo sapiens	?	-	?
2,4-dinitrophenyl-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg + H2O	-	Homo sapiens	?	-	?
2,4-Dinitrophenyl-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg-NH2 + H2O	-	Homo sapiens	2,4-Dinitrophenyl-Pro-Leu-Gly + Leu-Trp-Ala-D-Arg-NH2	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
3.5	-	2,4-dinitrophenyl-Pro-Leu-Gly-Leu-Trp-Ala-D-Arg	-	Homo sapiens
5	-	2,4-Dinitrophenyl-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser	-	Homo sapiens

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Release 2023.1 (January 2023)