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Literature summary for 3.4.24.23 extracted from
- Comparative sequence specificities of human 72- and 92-kDa gelatinases (type IV collagenases) and PUMP (matrilysin) (1993), Biochemistry, 32, 6427-6432.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.81 | - |
Gly-Pro-Gln-Ala-Ile-Ala-Gly-Gln | - |
Homo sapiens |  |
| 2 | - |
Gly-Pro-Gln-Gly-Ile-Ala-Gly-Gln | - |
Homo sapiens | |
| 2.3 | - |
Gly-Pro-Gln-Gly-Ile-Ala-Met-Gln | - |
Homo sapiens | |
| 4.2 | - |
Gly-Pro-Met-Gly-Ile-Ala-Gly-Gln | - |
Homo sapiens | |
| 7.3 | - |
Gly-Pro-Gln-Gly-Leu-Ala-Gly-Gln | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gly-Pro-Gln-Ala-Ile-Ala-Gly-Gln + H2O | - |
Homo sapiens | ? | - |
? | |
| Gly-Pro-Gln-Gly-Ile-Ala-Gly-Gln + H2O | - |
Homo sapiens | ? | - |
? | |
| Gly-Pro-Gln-Gly-Ile-Ala-Met-Gln + H2O | - |
Homo sapiens | ? | - |
? | |
| Gly-Pro-Gln-Gly-Leu-Ala-Gly-Gln + H2O | - |
Homo sapiens | ? | - |
? | |
| Gly-Pro-Met-Gly-Ile-Ala-Gly-Gln + H2O | - |
Homo sapiens | ? | - |
? | |
| additional information | specificity at subsite P1: tolerates small amino acids such as Gly and Ala, larger residues such as Met, Pro, Gln and Glu are also accomodated well | Homo sapiens | ? | - |
? | |
| additional information | at subsite P1': hydrophobic aliphatic residues preferred, strong preference for Leu | Homo sapiens | ? | - |
? | |
| additional information | at P3': prefers Met | Homo sapiens | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.222 | - |
Gly-Pro-Gln-Gly-Ile-Ala-Gly-Gln | - |
Homo sapiens | |
| 0.472 | - |
Gly-Pro-Gln-Ala-Ile-Ala-Gly-Gln | - |
Homo sapiens | |
| 1.17 | - |
Gly-Pro-Gln-Gly-Ile-Ala-Met-Gln | - |
Homo sapiens | |
| 1.92 | - |
Gly-Pro-Met-Gly-Ile-Ala-Gly-Gln | - |
Homo sapiens | |
| 2.47 | - |
Gly-Pro-Gln-Gly-Leu-Ala-Gly-Gln | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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