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Literature summary for 3.4.24.19 extracted from

  • Turtle, E.; Chow, N.; Yang, C.; Sosa, S.; Bauer, U.; Brenner, M.; Solow-Cordero, D.; Ho, W.B.
    Design and synthesis of procollagen C-proteinase inhibitors (2012), Bioorg. Med. Chem. Lett., 22, 7397-7401.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-acetyl-L-prolyl-L-tyrosyl-L-tyrosyl-N-hydroxyglycinamide
-
Homo sapiens
2-(N-((3s,5s,7s)-adamantan-1-yl)-4-methoxyphenylsulfonamido)-N-hydroxyacetamide 9-21% inhibition at 0.010 mM Homo sapiens
2-[[3-(hydroxyamino)-3-oxopropyl][2-(4-methoxyphenyl)ethyl]sulfamoyl]benzoic acid 32% inhibition at 0.010 mM Homo sapiens
4-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxybutanamide
-
Homo sapiens
4-[[3-(hydroxyamino)-3-oxopropyl](2-phenylethyl)sulfamoyl]benzoic acid
-
Homo sapiens
4-[[3-(hydroxyamino)-3-oxopropyl][2-(4-methoxyphenyl)ethyl]sulfamoyl]-N-phenylbenzamide
-
Homo sapiens
butyl [[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]acetate
-
Homo sapiens
additional information design from substrate leads and synthesis of procollagen C-proteinase inhibitors, overview. The compounds are optimized for potency and selectivity, with N-substituted aryl sulfonamide hydroxamates having the best combination of these properties Homo sapiens
N-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-phenylethyl)amino]butanamide
-
Homo sapiens
N-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](phenyl)amino]butanamide
-
Homo sapiens
N-hydroxy-N2-(4-methoxybenzyl)-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
Homo sapiens
N-hydroxy-N2-(4-methoxyphenyl)-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
Homo sapiens
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alpha-asparagine
-
Homo sapiens
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-(2-phenylethyl)glycinamide
-
Homo sapiens
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-phenylglycinamide
-
Homo sapiens
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-[4-(trifluoromethyl)benzyl]glycinamide
-
Homo sapiens
N-hydroxy-N2-[2-(4-methoxyphenyl)ethyl]-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
Homo sapiens
N-hydroxy-N3-(2-phenylethyl)-N3-(phenylsulfonyl)-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-(4-methoxyphenyl)-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-(2-phenylethyl)-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-phenyl-b-alaninamide
-
Homo sapiens
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-nitrophenyl)ethyl]-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-sulfamoylphenyl)ethyl]-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(morpholin-4-yl)ethyl]-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(pyridin-2-yl)ethyl]-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[(4-[[(4-methoxyphenyl)carbamoyl]amino]phenyl)sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[2-(2-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide 45% inhibition at 0.010 mM Homo sapiens
N-hydroxy-N3-[2-(3-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(methylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenoxycarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-[[(2-phenylethyl)carbamoyl]amino]phenyl)sulfonyl]-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[2-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-([[4-(trifluoromethyl)phenyl]carbamoyl]amino)phenyl]sulfonyl]-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[[2-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[[3-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
Homo sapiens
N-hydroxy-N3-[[4-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
Homo sapiens
N-[(hydroxyamino)methyl]-L-alpha-aspartyl-N-methyl-L-alpha-glutamine
-
Homo sapiens
N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(2-sulfanylethyl)benzenesulfonamide
-
Homo sapiens
N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(3-sulfanylpropyl)benzenesulfonamide
-
Homo sapiens
N-[2-[carbamoyl(hydroxy)amino]ethyl]-N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)benzenesulfonamide
-
Homo sapiens
N2-(4-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
Homo sapiens
N2-(4-fluorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
Homo sapiens
N2-(butylsulfonyl)-N-hydroxy-N2-[2-(4-methoxyphenyl)ethyl]glycinamide
-
Homo sapiens
N2-(diphenylmethyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
Homo sapiens
N2-benzyl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alpha-asparagine
-
Homo sapiens
N2-benzyl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
Homo sapiens
N2-butan-2-yl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
-
Homo sapiens
N2-[2-(4-methoxyphenyl)ethyl]-N2-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanylglycinamide
-
Homo sapiens
N2-[2-(carboxymethyl)-4-(hydroxyamino)-4-oxobutanoyl]-N-methyl-L-alpha-glutamine
-
Homo sapiens
N2-[3-carboxy-2-(sulfanylmethyl)propanoyl]-N-methyl-L-alpha-glutamine
-
Homo sapiens
N3-(butylsulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
Homo sapiens
N3-(cyclohexylmethyl)-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
Homo sapiens
N3-([4-[(biphenyl-4-ylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
Homo sapiens
N3-([4-[(diphenoxycarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
Homo sapiens
N3-([4-[(diphenylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
Homo sapiens
N3-([4-[amino(phenylsulfonyl)methyl]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
Homo sapiens
N3-benzyl-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
Homo sapiens
N3-butan-2-yl-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
Homo sapiens
N3-[(4-tert-butylphenyl)sulfonyl]-N-hydroxy-N3-(2-phenylethyl)-beta-alaninamide
-
Homo sapiens
N3-[(4-[[(4-chlorophenyl)carbamoyl]amino]phenyl)sulfonyl]-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
-
Homo sapiens
N3-[2-(3,4-dimethoxyphenyl)ethyl]-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
-
Homo sapiens
N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanyl-beta-alaninamide
-
Homo sapiens
[[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]acetic acid
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ a zinc metalloendopeptidase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme cleaves both pro-collagen and non-collagen substrates involved in forming functional collagen fibrils. Enzyme cleavage sequences in enzyme substrates types I, II, and III collagen indicate a substrate preference for P3 Met or Tyr, for P2 Arg or Tyr, for P1 Ala or Gly, for P1' Asp, for P2' Asp, Glu, or Gln; and for P3' Ala or Pro ?
-
?
pro-collagen type I + H2O Homo sapiens
-
?
-
?
pro-collagen type II + H2O Homo sapiens
-
?
-
?
pro-collagen type III + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
FAPYYGDEPMDF + H2O low enzyme activity Homo sapiens FAPYYG + DEPMDF
-
?
FYRADQPR + H2O
-
Homo sapiens FYRA + DQPR
-
?
additional information the enzyme cleaves both pro-collagen and non-collagen substrates involved in forming functional collagen fibrils. Enzyme cleavage sequences in enzyme substrates types I, II, and III collagen indicate a substrate preference for P3 Met or Tyr, for P2 Arg or Tyr, for P1 Ala or Gly, for P1' Asp, for P2' Asp, Glu, or Gln; and for P3' Ala or Pro Homo sapiens ?
-
?
additional information substrate specificity, overview, peptides PYYGD and PYYGAEPM are no sbstrates for the enzyme Homo sapiens ?
-
?
pro-collagen type I + H2O
-
Homo sapiens ?
-
?
pro-collagen type II + H2O
-
Homo sapiens ?
-
?
pro-collagen type III + H2O
-
Homo sapiens ?
-
?
PYYGDE + H2O
-
Homo sapiens PYYG + DE
-
?
PYYGDEP + H2O
-
Homo sapiens PYYG + DEP
-
?
PYYGDEPM + H2O high enzyme activity Homo sapiens PYYG + DEPM
-
?
YYGDEPM + H2O
-
Homo sapiens YYG + DEPM
-
?
YYRADDAN + H2O low enzyme activity Homo sapiens YYRA + DDAN
-
?

Synonyms

Synonyms Comment Organism
bone morphogenetic protein-1
-
Homo sapiens
PCP
-
Homo sapiens
Procollagen C-proteinase
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00001
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenoxycarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
0.00003
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-[[(2-phenylethyl)carbamoyl]amino]phenyl)sulfonyl]-beta-alaninamide
0.000042
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-([[4-(trifluoromethyl)phenyl]carbamoyl]amino)phenyl]sulfonyl]-beta-alaninamide
0.00006
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(methylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
0.000073
-
pH and temperature not specified in the publication Homo sapiens N3-([4-[(biphenyl-4-ylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
0.00008
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[[4-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
0.000093
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide
0.00029
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide
0.0003
-
pH and temperature not specified in the publication Homo sapiens N3-[(4-[[(4-chlorophenyl)carbamoyl]amino]phenyl)sulfonyl]-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
0.00035
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[(4-[[(4-methoxyphenyl)carbamoyl]amino]phenyl)sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
0.00038
-
pH and temperature not specified in the publication Homo sapiens N3-([4-[(diphenoxycarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
0.0004
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[[3-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
0.00041
-
pH and temperature not specified in the publication Homo sapiens 4-[[3-(hydroxyamino)-3-oxopropyl][2-(4-methoxyphenyl)ethyl]sulfamoyl]-N-phenylbenzamide
0.00047
-
pH and temperature not specified in the publication Homo sapiens N3-([4-[amino(phenylsulfonyl)methyl]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
0.00078
-
pH and temperature not specified in the publication Homo sapiens N3-([4-[(diphenylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
0.0009
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-(2-phenylethyl)-beta-alaninamide
0.001
-
pH and temperature not specified in the publication Homo sapiens 4-[[3-(hydroxyamino)-3-oxopropyl](2-phenylethyl)sulfamoyl]benzoic acid
0.001
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
0.001
-
pH and temperature not specified in the publication Homo sapiens N3-(cyclohexylmethyl)-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
0.0017
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-(4-methoxyphenyl)-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
0.0017
-
pH and temperature not specified in the publication Homo sapiens N3-butan-2-yl-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
0.0022
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-(2-phenylethyl)-N3-(phenylsulfonyl)-beta-alaninamide
0.0023
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[2-(3-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
0.0028
-
pH and temperature not specified in the publication Homo sapiens N2-benzyl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alpha-asparagine
0.003
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-phenyl-b-alaninamide
0.0045
-
pH and temperature not specified in the publication Homo sapiens N3-benzyl-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
0.0047
-
pH and temperature not specified in the publication Homo sapiens N2-[2-(4-methoxyphenyl)ethyl]-N2-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanylglycinamide
0.0049
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-phenylethyl)amino]butanamide
0.0067
-
pH and temperature not specified in the publication Homo sapiens N3-(butylsulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
0.0071
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[[2-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide
0.0081
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(pyridin-2-yl)ethyl]-beta-alaninamide
0.0091
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[2-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide
0.0094
-
pH and temperature not specified in the publication Homo sapiens N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(2-sulfanylethyl)benzenesulfonamide
0.01
-
pH and temperature not specified in the publication Homo sapiens 4-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxybutanamide
0.01
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alpha-asparagine
0.011
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-nitrophenyl)ethyl]-beta-alaninamide
0.013
-
pH and temperature not specified in the publication Homo sapiens N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanyl-beta-alaninamide
0.014
-
pH and temperature not specified in the publication Homo sapiens N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(3-sulfanylpropyl)benzenesulfonamide
0.016
-
pH and temperature not specified in the publication Homo sapiens N2-benzyl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
0.017
-
pH and temperature not specified in the publication Homo sapiens N3-[(4-tert-butylphenyl)sulfonyl]-N-hydroxy-N3-(2-phenylethyl)-beta-alaninamide
0.018
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N2-[2-(4-methoxyphenyl)ethyl]-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
0.018
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-(2-phenylethyl)glycinamide
0.019
-
pH and temperature not specified in the publication Homo sapiens N2-(4-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
0.023
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-sulfamoylphenyl)ethyl]-beta-alaninamide
0.028
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](phenyl)amino]butanamide
0.029
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N2-(4-methoxybenzyl)-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
0.034
-
pH and temperature not specified in the publication Homo sapiens N2-(4-fluorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
0.04
-
pH and temperature not specified in the publication Homo sapiens N2-[2-(carboxymethyl)-4-(hydroxyamino)-4-oxobutanoyl]-N-methyl-L-alpha-glutamine
0.042
-
pH and temperature not specified in the publication Homo sapiens 1-acetyl-L-prolyl-L-tyrosyl-L-tyrosyl-N-hydroxyglycinamide
0.042
-
pH and temperature not specified in the publication Homo sapiens N3-[2-(3,4-dimethoxyphenyl)ethyl]-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
0.055
-
pH and temperature not specified in the publication Homo sapiens N2-(butylsulfonyl)-N-hydroxy-N2-[2-(4-methoxyphenyl)ethyl]glycinamide
0.067
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-[4-(trifluoromethyl)benzyl]glycinamide
0.069
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-phenylglycinamide
0.073
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N2-(4-methoxyphenyl)-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
0.081
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(morpholin-4-yl)ethyl]-beta-alaninamide
0.085
-
pH and temperature not specified in the publication Homo sapiens N2-[3-carboxy-2-(sulfanylmethyl)propanoyl]-N-methyl-L-alpha-glutamine
0.1
-
above, pH and temperature not specified in the publication Homo sapiens N-[2-[carbamoyl(hydroxy)amino]ethyl]-N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)benzenesulfonamide
0.102
-
pH and temperature not specified in the publication Homo sapiens N2-(diphenylmethyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
0.112
-
pH and temperature not specified in the publication Homo sapiens N2-butan-2-yl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide
0.166
-
pH and temperature not specified in the publication Homo sapiens N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide
0.167
-
pH and temperature not specified in the publication Homo sapiens butyl [[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]acetate
0.345
-
pH and temperature not specified in the publication Homo sapiens [[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]acetic acid
1.5
-
pH and temperature not specified in the publication Homo sapiens N-[(hydroxyamino)methyl]-L-alpha-aspartyl-N-methyl-L-alpha-glutamine

General Information

General Information Comment Organism
evolution the enzyme belongs to the astacin family Homo sapiens
malfunction Inhibition of the enzyme is expected to disrupt fibril formation and stability, preventing the excess collagen deposition associated with fibrosis Homo sapiens
physiological function types I-III collagens are initially excreted as pro-collagen peptides which contain solubilizing N and C terminal sequences. The enzyme cleaves both pro-collagen and non-collagen substrates involved in forming functional collagen fibrils. Cleavage of the globular C-terminal sequence is necessary to convert soluble pro-collagens into fully formed, insoluble, collagen fibrils. In addition, PCP processes prolysyl oxidase to its active form, which catalyzes the crosslinking of collagens, contributing to the structural stability of collagen fibrils Homo sapiens