Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-acetyl-L-prolyl-L-tyrosyl-L-tyrosyl-N-hydroxyglycinamide | - |
Homo sapiens | |
2-(N-((3s,5s,7s)-adamantan-1-yl)-4-methoxyphenylsulfonamido)-N-hydroxyacetamide | 9-21% inhibition at 0.010 mM | Homo sapiens | |
2-[[3-(hydroxyamino)-3-oxopropyl][2-(4-methoxyphenyl)ethyl]sulfamoyl]benzoic acid | 32% inhibition at 0.010 mM | Homo sapiens | |
4-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxybutanamide | - |
Homo sapiens | |
4-[[3-(hydroxyamino)-3-oxopropyl](2-phenylethyl)sulfamoyl]benzoic acid | - |
Homo sapiens | |
4-[[3-(hydroxyamino)-3-oxopropyl][2-(4-methoxyphenyl)ethyl]sulfamoyl]-N-phenylbenzamide | - |
Homo sapiens | |
butyl [[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]acetate | - |
Homo sapiens | |
additional information | design from substrate leads and synthesis of procollagen C-proteinase inhibitors, overview. The compounds are optimized for potency and selectivity, with N-substituted aryl sulfonamide hydroxamates having the best combination of these properties | Homo sapiens | |
N-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-phenylethyl)amino]butanamide | - |
Homo sapiens | |
N-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](phenyl)amino]butanamide | - |
Homo sapiens | |
N-hydroxy-N2-(4-methoxybenzyl)-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | - |
Homo sapiens | |
N-hydroxy-N2-(4-methoxyphenyl)-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | - |
Homo sapiens | |
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alpha-asparagine | - |
Homo sapiens | |
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-(2-phenylethyl)glycinamide | - |
Homo sapiens | |
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-phenylglycinamide | - |
Homo sapiens | |
N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-[4-(trifluoromethyl)benzyl]glycinamide | - |
Homo sapiens | |
N-hydroxy-N2-[2-(4-methoxyphenyl)ethyl]-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | - |
Homo sapiens | |
N-hydroxy-N3-(2-phenylethyl)-N3-(phenylsulfonyl)-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-(4-methoxyphenyl)-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-(2-phenylethyl)-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-phenyl-b-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-nitrophenyl)ethyl]-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-sulfamoylphenyl)ethyl]-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(morpholin-4-yl)ethyl]-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(pyridin-2-yl)ethyl]-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[(4-[[(4-methoxyphenyl)carbamoyl]amino]phenyl)sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[2-(2-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | 45% inhibition at 0.010 mM | Homo sapiens | |
N-hydroxy-N3-[2-(3-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(methylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenoxycarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-[[(2-phenylethyl)carbamoyl]amino]phenyl)sulfonyl]-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[2-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-([[4-(trifluoromethyl)phenyl]carbamoyl]amino)phenyl]sulfonyl]-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[[2-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[[3-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | - |
Homo sapiens | |
N-hydroxy-N3-[[4-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | - |
Homo sapiens | |
N-[(hydroxyamino)methyl]-L-alpha-aspartyl-N-methyl-L-alpha-glutamine | - |
Homo sapiens | |
N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(2-sulfanylethyl)benzenesulfonamide | - |
Homo sapiens | |
N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(3-sulfanylpropyl)benzenesulfonamide | - |
Homo sapiens | |
N-[2-[carbamoyl(hydroxy)amino]ethyl]-N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)benzenesulfonamide | - |
Homo sapiens | |
N2-(4-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | - |
Homo sapiens | |
N2-(4-fluorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | - |
Homo sapiens | |
N2-(butylsulfonyl)-N-hydroxy-N2-[2-(4-methoxyphenyl)ethyl]glycinamide | - |
Homo sapiens | |
N2-(diphenylmethyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | - |
Homo sapiens | |
N2-benzyl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alpha-asparagine | - |
Homo sapiens | |
N2-benzyl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | - |
Homo sapiens | |
N2-butan-2-yl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | - |
Homo sapiens | |
N2-[2-(4-methoxyphenyl)ethyl]-N2-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanylglycinamide | - |
Homo sapiens | |
N2-[2-(carboxymethyl)-4-(hydroxyamino)-4-oxobutanoyl]-N-methyl-L-alpha-glutamine | - |
Homo sapiens | |
N2-[3-carboxy-2-(sulfanylmethyl)propanoyl]-N-methyl-L-alpha-glutamine | - |
Homo sapiens | |
N3-(butylsulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | - |
Homo sapiens | |
N3-(cyclohexylmethyl)-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | - |
Homo sapiens | |
N3-([4-[(biphenyl-4-ylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | - |
Homo sapiens | |
N3-([4-[(diphenoxycarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | - |
Homo sapiens | |
N3-([4-[(diphenylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | - |
Homo sapiens | |
N3-([4-[amino(phenylsulfonyl)methyl]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | - |
Homo sapiens | |
N3-benzyl-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | - |
Homo sapiens | |
N3-butan-2-yl-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | - |
Homo sapiens | |
N3-[(4-tert-butylphenyl)sulfonyl]-N-hydroxy-N3-(2-phenylethyl)-beta-alaninamide | - |
Homo sapiens | |
N3-[(4-[[(4-chlorophenyl)carbamoyl]amino]phenyl)sulfonyl]-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | - |
Homo sapiens | |
N3-[2-(3,4-dimethoxyphenyl)ethyl]-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | - |
Homo sapiens | |
N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanyl-beta-alaninamide | - |
Homo sapiens | |
[[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]acetic acid | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | a zinc metalloendopeptidase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme cleaves both pro-collagen and non-collagen substrates involved in forming functional collagen fibrils. Enzyme cleavage sequences in enzyme substrates types I, II, and III collagen indicate a substrate preference for P3 Met or Tyr, for P2 Arg or Tyr, for P1 Ala or Gly, for P1' Asp, for P2' Asp, Glu, or Gln; and for P3' Ala or Pro | ? | - |
? | |
pro-collagen type I + H2O | Homo sapiens | - |
? | - |
? | |
pro-collagen type II + H2O | Homo sapiens | - |
? | - |
? | |
pro-collagen type III + H2O | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
FAPYYGDEPMDF + H2O | low enzyme activity | Homo sapiens | FAPYYG + DEPMDF | - |
? | |
FYRADQPR + H2O | - |
Homo sapiens | FYRA + DQPR | - |
? | |
additional information | the enzyme cleaves both pro-collagen and non-collagen substrates involved in forming functional collagen fibrils. Enzyme cleavage sequences in enzyme substrates types I, II, and III collagen indicate a substrate preference for P3 Met or Tyr, for P2 Arg or Tyr, for P1 Ala or Gly, for P1' Asp, for P2' Asp, Glu, or Gln; and for P3' Ala or Pro | Homo sapiens | ? | - |
? | |
additional information | substrate specificity, overview, peptides PYYGD and PYYGAEPM are no sbstrates for the enzyme | Homo sapiens | ? | - |
? | |
pro-collagen type I + H2O | - |
Homo sapiens | ? | - |
? | |
pro-collagen type II + H2O | - |
Homo sapiens | ? | - |
? | |
pro-collagen type III + H2O | - |
Homo sapiens | ? | - |
? | |
PYYGDE + H2O | - |
Homo sapiens | PYYG + DE | - |
? | |
PYYGDEP + H2O | - |
Homo sapiens | PYYG + DEP | - |
? | |
PYYGDEPM + H2O | high enzyme activity | Homo sapiens | PYYG + DEPM | - |
? | |
YYGDEPM + H2O | - |
Homo sapiens | YYG + DEPM | - |
? | |
YYRADDAN + H2O | low enzyme activity | Homo sapiens | YYRA + DDAN | - |
? |
Synonyms | Comment | Organism |
---|---|---|
bone morphogenetic protein-1 | - |
Homo sapiens |
PCP | - |
Homo sapiens |
Procollagen C-proteinase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00001 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenoxycarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide | |
0.00003 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-[[(2-phenylethyl)carbamoyl]amino]phenyl)sulfonyl]-beta-alaninamide | |
0.000042 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-([[4-(trifluoromethyl)phenyl]carbamoyl]amino)phenyl]sulfonyl]-beta-alaninamide | |
0.00006 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(methylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide | |
0.000073 | - |
pH and temperature not specified in the publication | Homo sapiens | N3-([4-[(biphenyl-4-ylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | |
0.00008 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[[4-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | |
0.000093 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-([4-[(phenylcarbamoyl)amino]phenyl]sulfonyl)-beta-alaninamide | |
0.00029 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide | |
0.0003 | - |
pH and temperature not specified in the publication | Homo sapiens | N3-[(4-[[(4-chlorophenyl)carbamoyl]amino]phenyl)sulfonyl]-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | |
0.00035 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[(4-[[(4-methoxyphenyl)carbamoyl]amino]phenyl)sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | |
0.00038 | - |
pH and temperature not specified in the publication | Homo sapiens | N3-([4-[(diphenoxycarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | |
0.0004 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[[3-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | |
0.00041 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[[3-(hydroxyamino)-3-oxopropyl][2-(4-methoxyphenyl)ethyl]sulfamoyl]-N-phenylbenzamide | |
0.00047 | - |
pH and temperature not specified in the publication | Homo sapiens | N3-([4-[amino(phenylsulfonyl)methyl]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | |
0.00078 | - |
pH and temperature not specified in the publication | Homo sapiens | N3-([4-[(diphenylcarbamoyl)amino]phenyl]sulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | |
0.0009 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-(2-phenylethyl)-beta-alaninamide | |
0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[[3-(hydroxyamino)-3-oxopropyl](2-phenylethyl)sulfamoyl]benzoic acid | |
0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | |
0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | N3-(cyclohexylmethyl)-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | |
0.0017 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-(4-methoxyphenyl)-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | |
0.0017 | - |
pH and temperature not specified in the publication | Homo sapiens | N3-butan-2-yl-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | |
0.0022 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-(2-phenylethyl)-N3-(phenylsulfonyl)-beta-alaninamide | |
0.0023 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[2-(3-methoxyphenyl)ethyl]-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | |
0.0028 | - |
pH and temperature not specified in the publication | Homo sapiens | N2-benzyl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alpha-asparagine | |
0.003 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-phenyl-b-alaninamide | |
0.0045 | - |
pH and temperature not specified in the publication | Homo sapiens | N3-benzyl-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | |
0.0047 | - |
pH and temperature not specified in the publication | Homo sapiens | N2-[2-(4-methoxyphenyl)ethyl]-N2-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanylglycinamide | |
0.0049 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](2-phenylethyl)amino]butanamide | |
0.0067 | - |
pH and temperature not specified in the publication | Homo sapiens | N3-(butylsulfonyl)-N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | |
0.0071 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[[2-(N'-hydroxycarbamimidoyl)phenyl]sulfonyl]-N3-[2-(4-methoxyphenyl)ethyl]-beta-alaninamide | |
0.0081 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(pyridin-2-yl)ethyl]-beta-alaninamide | |
0.0091 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[2-(4-methoxyphenyl)ethyl]-N3-[[2-(methylsulfonyl)phenyl]sulfonyl]-beta-alaninamide | |
0.0094 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(2-sulfanylethyl)benzenesulfonamide | |
0.01 | - |
pH and temperature not specified in the publication | Homo sapiens | 4-[benzyl[(4-methoxyphenyl)sulfonyl]amino]-N-hydroxybutanamide | |
0.01 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-L-alpha-asparagine | |
0.011 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-nitrophenyl)ethyl]-beta-alaninamide | |
0.013 | - |
pH and temperature not specified in the publication | Homo sapiens | N3-[2-(4-methoxyphenyl)ethyl]-N3-[[4-(methylsulfonyl)phenyl]sulfonyl]-N-sulfanyl-beta-alaninamide | |
0.014 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)-N-(3-sulfanylpropyl)benzenesulfonamide | |
0.016 | - |
pH and temperature not specified in the publication | Homo sapiens | N2-benzyl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | |
0.017 | - |
pH and temperature not specified in the publication | Homo sapiens | N3-[(4-tert-butylphenyl)sulfonyl]-N-hydroxy-N3-(2-phenylethyl)-beta-alaninamide | |
0.018 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N2-[2-(4-methoxyphenyl)ethyl]-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | |
0.018 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-(2-phenylethyl)glycinamide | |
0.019 | - |
pH and temperature not specified in the publication | Homo sapiens | N2-(4-chlorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | |
0.023 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(4-sulfamoylphenyl)ethyl]-beta-alaninamide | |
0.028 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-4-[[(4-methoxyphenyl)sulfonyl](phenyl)amino]butanamide | |
0.029 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N2-(4-methoxybenzyl)-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | |
0.034 | - |
pH and temperature not specified in the publication | Homo sapiens | N2-(4-fluorobenzyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | |
0.04 | - |
pH and temperature not specified in the publication | Homo sapiens | N2-[2-(carboxymethyl)-4-(hydroxyamino)-4-oxobutanoyl]-N-methyl-L-alpha-glutamine | |
0.042 | - |
pH and temperature not specified in the publication | Homo sapiens | 1-acetyl-L-prolyl-L-tyrosyl-L-tyrosyl-N-hydroxyglycinamide | |
0.042 | - |
pH and temperature not specified in the publication | Homo sapiens | N3-[2-(3,4-dimethoxyphenyl)ethyl]-N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | |
0.055 | - |
pH and temperature not specified in the publication | Homo sapiens | N2-(butylsulfonyl)-N-hydroxy-N2-[2-(4-methoxyphenyl)ethyl]glycinamide | |
0.067 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-[4-(trifluoromethyl)benzyl]glycinamide | |
0.069 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-phenylglycinamide | |
0.073 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N2-(4-methoxyphenyl)-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | |
0.081 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-N3-[2-(morpholin-4-yl)ethyl]-beta-alaninamide | |
0.085 | - |
pH and temperature not specified in the publication | Homo sapiens | N2-[3-carboxy-2-(sulfanylmethyl)propanoyl]-N-methyl-L-alpha-glutamine | |
0.1 | - |
above, pH and temperature not specified in the publication | Homo sapiens | N-[2-[carbamoyl(hydroxy)amino]ethyl]-N-[2-(4-methoxyphenyl)ethyl]-4-(methylsulfonyl)benzenesulfonamide | |
0.102 | - |
pH and temperature not specified in the publication | Homo sapiens | N2-(diphenylmethyl)-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | |
0.112 | - |
pH and temperature not specified in the publication | Homo sapiens | N2-butan-2-yl-N-hydroxy-N2-[(4-methoxyphenyl)sulfonyl]glycinamide | |
0.166 | - |
pH and temperature not specified in the publication | Homo sapiens | N-hydroxy-N3-[(4-methoxyphenyl)sulfonyl]-beta-alaninamide | |
0.167 | - |
pH and temperature not specified in the publication | Homo sapiens | butyl [[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]acetate | |
0.345 | - |
pH and temperature not specified in the publication | Homo sapiens | [[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]acetic acid | |
1.5 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[(hydroxyamino)methyl]-L-alpha-aspartyl-N-methyl-L-alpha-glutamine |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the astacin family | Homo sapiens |
malfunction | Inhibition of the enzyme is expected to disrupt fibril formation and stability, preventing the excess collagen deposition associated with fibrosis | Homo sapiens |
physiological function | types I-III collagens are initially excreted as pro-collagen peptides which contain solubilizing N and C terminal sequences. The enzyme cleaves both pro-collagen and non-collagen substrates involved in forming functional collagen fibrils. Cleavage of the globular C-terminal sequence is necessary to convert soluble pro-collagens into fully formed, insoluble, collagen fibrils. In addition, PCP processes prolysyl oxidase to its active form, which catalyzes the crosslinking of collagens, contributing to the structural stability of collagen fibrils | Homo sapiens |