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Literature summary for 3.4.24.19 extracted from
- Partial purification of a procollagen C-proteinase. Inhibition by synthetic peptides and sequential cleavage of type I procollagen (1982), Biochemistry, 21, 757-764.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Gallus gallus |  |
| 2,2'-dipyridyl | - |
Gallus gallus | |
| DTT | - |
Gallus gallus | |
| EDTA | - |
Gallus gallus | |
| Fetal calf serum | - |
Gallus gallus | |
| metal chelators | - |
Gallus gallus | |
| additional information | not: cysteine proteinases; not: inhibitors of serine | Gallus gallus | |
| Synthetic peptides | with amino acid sequences similar to the amino acid sequence around the sites at which the C-propeptides are cleaved during the conversion of procollagen to collagen in vivo, e.g. Tyr-Tyr-Arg-Ala-Asp-Asp-Ala, 35-60% inhibition at 6-12 mM, shorter peptides containing the Ala-Asp bond cleaved by the enzyme are less effective | Gallus gallus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 80000 | - |
gel filtration | Gallus gallus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone | membranous bones of chick embryos | Gallus gallus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Gallus gallus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | in a reaction with modified procollagen the enzyme preferentially cleaves the C-propeptides from the pro-alpha chains in the order pro-alpha1, pro-alpha1 and then pro-alpha2 | Gallus gallus | ? | - |
? | |
| Procollagen type I + H2O | - |
Gallus gallus | Type I pNcollagen + C-propeptides | - |
? | |
| Procollagen type II + H2O | - |
Gallus gallus | Type II pNcollagen + C-propeptides | - |
? | |
| Procollagen type III + H2O | - |
Gallus gallus | Type III pNcollagen + C-propeptides | - |
? | |
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