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Literature summary for 3.4.24.18 extracted from

  • Garcํa-Caballero, A.; Ishmael, S.; Dang, Y.; Gillie, D.; Bond, J.; Milgram, S.; Stutts, M.
    Activation of the epithelial sodium channel by the metalloprotease meprin beta subunit (2011), Channels, 5, 14-22.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
actinonin
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens meprin interacts with epithelial Na+ channel (ENaC) ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information meprin interacts with epithelial Na+ channel (ENaC) Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
meprin A
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function meprins stimulate epithelial Na+ channel (ENaC) expressed exogenously in Xenopus oocytes and endogenously in epithelial cells. Co-expression of ENaC subunits and meprin beta or alpha/beta in Xenopus oocytes increases amiloride-sensitive Na+ currents 2fold. The meprin-mediated increase in ENaC currents in oocytes and epithelial cell monolayers requires meprin beta, but not the alpha subunit Homo sapiens