Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.18 extracted from

  • Schuette, A.; Hedrich, J.; Stoecker, W.; Becker-Pauly, C.
    Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2 (2010), PLoS ONE, 5, e8835.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.18

Application

Application Comment Organism
medicine meprin alpha is a therapeutic target in cardiovascular diseases or in tumor growth inhibition Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Danio rerio B3DKP9
-
-
Danio rerio Q5RHM1
-
-
Homo sapiens Q16819
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Danio rerio
-
embryo
-
 Homo sapiens
-
epidermis
-
 Danio rerio
-
epidermis
-
 Homo sapiens
-
intestine
-
 Danio rerio
-
intestine
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
vascular endothelial growth factor-A + H2O
-
 Danio rerio ?
-
 ?
vascular endothelial growth factor-A + H2O cleavage of the vascular endothelial growth factor-A monomer by meprin alpha yields in two distinct fragments of 19600 Da, the N-terminal cleavage site in human vascular endothelial growth factor-A165 is between Ala30 and Glu31 due to recombinant human meprin alpha activity Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
meprin alpha
-
 Homo sapiens
meprin alpha1
-
 Danio rerio
meprin alpha2
-
 Danio rerio

General Information

General Information Comment Organism
malfunction knockdown of meprin alpah1 mRNA causes defects in general tissue differentiation Danio rerio
malfunction meprin alpha2 morphants show severe failures in the formation of the vascular system Danio rerio
physiological function meprin metalloproteases are important for cell differentiation and proliferation already during embryogenesis, predominantly by the activation of growth factors. Meprins play a significant role in vascular endothelial growth factor-A processing, subsequently regulating angiogenesis Homo sapiens
physiological function meprin metalloproteases are important for cell differentiation and proliferation already during embryogenesis, predominantly by the activation of growth factors. Meprins play a significant role in VEGF-A processing, subsequently regulating angiogenesis Danio rerio