Activating Compound | Comment | Organism | Structure |
---|---|---|---|
KLK4 | activator of meprin beta | Homo sapiens | |
KLK5 | activator of meprin alpha and beta | Homo sapiens | |
KLK8 | activator of meprin beta | Homo sapiens | |
additional information | alpha- and beta-tryptase, urokinase plasminogen activator, KLK2, KLK6, KLK7, and KLK11 do not activate meprin alpha and beta | Homo sapiens | |
neutrophil elastase | activator of meprin alpha | Homo sapiens | |
plasmin | activator of meprin alpha | Homo sapiens | |
Trypsin | activator of meprin alpha and beta | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen type IV + H2O | Homo sapiens | meprin alpha can degrade collagen type IV | ? | - |
? | |
interleukin-1beta + H2O | Homo sapiens | meprin beta activates interleukin 18 | ? | - |
? | |
procollagen III + H2O | Homo sapiens | meprin alpha can process procollagen III | ? | - |
? | |
tissue growth factor-alpha + H2O | Homo sapiens | meprin alpha can process tissue growth factor-alpha | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | in human epidermis, meprin alpha is expressed exclusively in the keratinocytes of the stratum basale, whereas meprin beta is restricted to the cells of the stratum granulosum | Homo sapiens | - |
skin | in skin, meprins are located in separate layers of human epidermis | Homo sapiens | - |
stratum basale | in human epidermis, meprin alpha is expressed exclusively in the keratinocytes of the stratum basale | Homo sapiens | - |
stratum granulosum | in human epidermis, meprin beta is restricted to the cells of the stratum granulosum | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
collagen type IV + H2O | meprin alpha can degrade collagen type IV | Homo sapiens | ? | - |
? | |
interleukin-1beta + H2O | meprin beta activates interleukin 18 | Homo sapiens | ? | - |
? | |
pro-KLK7 + H2O | meprin beta cleaves pro-KLK7 between Gly17 and Asp18 | Homo sapiens | KLK7 + ? | - |
? | |
procollagen III + H2O | meprin alpha can process procollagen III | Homo sapiens | ? | - |
? | |
tissue growth factor-alpha + H2O | meprin alpha can process tissue growth factor-alpha | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
meprin alpha | - |
Homo sapiens |
meprin beta | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | meprin beta induces a dramatic change in cell morphology and a significant reduction in cell number, whereas meprin alpha plays a role for basal keratinocyte proliferation in vitro | Homo sapiens |