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Literature summary for 3.4.24.18 extracted from
- Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats (2008), Eur. J. Pharmacol., 581, 157-163.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | ischemic acute kidney injury was induced by occlusion of the left renal artery and vein for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. At 24 h after reperfusion, renal function and histology of both males and females showed significant deterioration. The degrees of renal dysfunction and histological damage are much more severe in males than in females. Pre-ischemic treatment with actinonin at 10 or 30 mg/kg i.v., dose-ependently attenuats the ischemia/reperfusion-induced renal injury in male rats, but fails to improve the renal injury in female rats. Verapamil at 1 mg/kg i.v., can efficiently prevent the ischemic acute kidney injury in female rats, as well as male rats | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| actinonin | pre-ischemic treatment with actinonin at 10 or 30 mg/kg, i.v. dose-ependently attenuates the ischemia/reperfusion-induced renal injury in male rats, but fails to improve the renal injury in female rats | Rattus norvegicus |  |
| verapamil | verapamil at 1 mg/kg, i.v. can efficiently prevent the ischemic acute kidney injury in female rats, as well as male rats | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Rattus norvegicus | - |
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