Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | - |
Homo sapiens | |
chymostatin | - |
Homo sapiens | |
DTT | strong | Homo sapiens | |
EDTA | - |
Homo sapiens | |
EGTA | - |
Homo sapiens | |
GSH | - |
Homo sapiens | |
additional information | inhibitors of elastase, aminopeptidase, serine, aspartic or cysteic proteases; no inhibition by phosphoramidon | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
microvillus | - |
Homo sapiens | 5902 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
91000 | - |
2 * 91000, human, SDS-PAGE, reducing conditions | Homo sapiens |
200000 | - |
human, SDS-PAGE, non-reducing conditions | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Parathyroid hormone + H2O | Homo sapiens | involved in PTH-degradation in human kidney | ? | - |
? | |
Parathyroid hormone + H2O | Homo sapiens PPH | involved in PTH-degradation in human kidney | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
PPH | - |
Homo sapiens PPH | - |
PPH | - |
Purification (Comment) | Organism |
---|---|
to near homogeneity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Benzyloxycarbonyl-Arg-Arg 4-methylcoumarin 7-amide + H2O | poor substrate, hydrolysis at 8.2% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide | Homo sapiens | ? | - |
? | |
Benzyloxycarbonyl-Arg-Arg 4-methylcoumarin 7-amide + H2O | poor substrate, hydrolysis at 8.2% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide | Homo sapiens PPH | ? | - |
? | |
Benzyloxycarbonyl-Glu-Lys-Lys 4-methylcoumarin 7-amide + H2O | poor substrate, hydrolysis at 9.1% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide | Homo sapiens | ? | - |
? | |
Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide + H2O | poor substrate, hydrolysis at 3.6% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide | Homo sapiens | ? | - |
? | |
Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide + H2O | poor substrate, hydrolysis at 3.6% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide | Homo sapiens PPH | ? | - |
? | |
Benzyloxycarbonyl-Val-Leu-Lys 4-methylcoumarin 7-amide + H2O | poor substrate, hydrolysis at 10.4% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide | Homo sapiens | ? | - |
? | |
Glutaryl-Phe 4-methylcoumarin 7-amide + H2O | poor substrate, hydrolysis at 2.4% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide | Homo sapiens | ? | - |
? | |
Leu-Val-Tyr 4-methylcoumarin 7-amide + H2O | poor substrate, hydrolysis at 6.2% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide | Homo sapiens | ? | - |
? | |
additional information | poor substrates are compounds with 3 or less amino acids | Homo sapiens | ? | - |
? | |
additional information | poor substrates are compounds with 3 or less amino acids | Homo sapiens PPH | ? | - |
? | |
Parathyroid hormone + H2O | involved in PTH-degradation in human kidney | Homo sapiens | ? | - |
? | |
Parathyroid hormone + H2O | involved in PTH-degradation in human kidney | Homo sapiens PPH | ? | - |
? | |
Parathyroid hormone + H2O | i.e. hPTH-(1-84), in vivo and in vitro | Homo sapiens | Hydrolyzed parathyroid hormone | - |
? | |
Succinyl-Ala-Ala-Pro-Phe 4-methylcoumarin 7-amide + H2O | poor substrate, hydrolysis at 9% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide | Homo sapiens | ? | - |
? | |
Succinyl-Ala-Pro-Ala 4-methylcoumarin 7-amide + H2O | poor substrate, hydrolysis at 2.8% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide | Homo sapiens | ? | - |
? | |
Succinyl-Gly-Pro 4-methylcoumarin 7-amide + H2O | poor substrate, hydrolysis at 10.7% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide | Homo sapiens | ? | - |
? | |
Succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide + H2O | - |
Homo sapiens | ? | - |
? | |
Succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide + H2O | - |
Homo sapiens PPH | ? | - |
? | |
Succinyl-Leu-Tyr 4-methylcoumarin 7-amide + H2O | poor substrate, hydrolysis at 5.6% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide | Homo sapiens | ? | - |
? | |
Tyr 4-methylcoumarin 7-amide + H2O | poor substrate, hydrolysis at 3.3% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 91000, human, SDS-PAGE, reducing conditions | Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |