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Literature summary for 3.4.24.18 extracted from

  • Yamaguchi, T.; Fukase, M.; Sugimoto, T.; Kido, H.; Chihara, K.
    Purification of meprin from human kidney and its role in parathyroid hormone degradation (1994), Biol. Chem. Hoppe-Seyler, 375, 821-824.
    View publication on PubMed
Search for more literature for 3.4.24.18

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Homo sapiens
chymostatin
-
 Homo sapiens
DTT strong Homo sapiens
EDTA
-
 Homo sapiens
EGTA
-
 Homo sapiens
GSH
-
 Homo sapiens
additional information inhibitors of elastase, aminopeptidase, serine, aspartic or cysteic proteases; no inhibition by phosphoramidon Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
microvillus
-
 Homo sapiens 5902
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
91000
-
 2 * 91000, human, SDS-PAGE, reducing conditions Homo sapiens
200000
-
 human, SDS-PAGE, non-reducing conditions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Parathyroid hormone + H2O Homo sapiens involved in PTH-degradation in human kidney ?
-
 ?
Parathyroid hormone + H2O Homo sapiens PPH involved in PTH-degradation in human kidney ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 PPH
-
Homo sapiens PPH
-
 PPH
-

Purification (Commentary)

Purification (Comment) Organism
to near homogeneity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Benzyloxycarbonyl-Arg-Arg 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 8.2% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
Benzyloxycarbonyl-Arg-Arg 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 8.2% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens PPH ?
-
 ?
Benzyloxycarbonyl-Glu-Lys-Lys 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 9.1% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 3.6% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 3.6% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens PPH ?
-
 ?
Benzyloxycarbonyl-Val-Leu-Lys 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 10.4% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
Glutaryl-Phe 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 2.4% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
Leu-Val-Tyr 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 6.2% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
additional information poor substrates are compounds with 3 or less amino acids Homo sapiens ?
-
 ?
additional information poor substrates are compounds with 3 or less amino acids Homo sapiens PPH ?
-
 ?
Parathyroid hormone + H2O involved in PTH-degradation in human kidney Homo sapiens ?
-
 ?
Parathyroid hormone + H2O involved in PTH-degradation in human kidney Homo sapiens PPH ?
-
 ?
Parathyroid hormone + H2O i.e. hPTH-(1-84), in vivo and in vitro Homo sapiens Hydrolyzed parathyroid hormone
-
 ?
Succinyl-Ala-Ala-Pro-Phe 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 9% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
Succinyl-Ala-Pro-Ala 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 2.8% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
Succinyl-Gly-Pro 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 10.7% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
Succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
Succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens PPH ?
-
 ?
Succinyl-Leu-Tyr 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 5.6% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?
Tyr 4-methylcoumarin 7-amide + H2O poor substrate, hydrolysis at 3.3% the rate of succinyl-Leu-Leu-Val-Tyr 4-methylcoumarin 7-amide Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 91000, human, SDS-PAGE, reducing conditions Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens