Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P08254 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cancer cell | - |
Homo sapiens | - |
epithelial cell | - |
Homo sapiens | - |
PA-TU-8988T cell | transcriptional profiling, overview | Homo sapiens | - |
pancreatic acinar cell | - |
Homo sapiens | - |
pancreatic ductal adenocarcinoma cell | the enzyme expression is associated with expression of Rac1b, a tumorigenic splice isoform of Rac1, in all stages of pancreatic cancer, analysis of 140 specimen, overview | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
MMP3 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | coexpression of MMP3 with activated KRAS in pancreatic acinar cells stimulates metaplasia and immune cell infiltration, priming the stromal microenvironment for early tumor development in a transgenic mouse model | Homo sapiens |
physiological function | enzyme MMP3 acts as a coconspirator of oncogenic KRAS in pancreatic cancer tumorigenesis and progression, both through Rac1b-mediated phenotypic control of pancreatic cancer cells themselves, and by giving rise to the tumorigenic microenvironment, tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma, overview | Homo sapiens |