Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.17 extracted from

  • Batra, J.; Robinson, J.; Soares, A.; Fields, A.; Radisky, D.; Radisky, E.
    Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: Binding studies and crystal structure (2012), J. Biol. Chem., 287, 15935-15946.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information purified proMMP-3-catalytic domain is activated overnight in the presence of the organomercurial compound 4-aminophenyl mercuric acetate Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure analysis of the isolated catalytic enzyme domain in complex with inhibitor TIMP1, PDB ID 1UEA Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
tissue inhibitor of metalloproteinases 1 TIMP-1, enzyme binding structure analysis and mechanism of inhibition, detailed overview and comparison to stromelysin-2, EC 3.4.24.22 Homo sapiens
tissue inhibitor of metalloproteinases 2 TIMP-2 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme degrades a variety of extracellular matrix proteins, including collagen types III-V and fibronectin, and also activate other proteases, including MMP-1, MMP-7, MMP-8, and MMP-9 ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08254
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme degrades a variety of extracellular matrix proteins, including collagen types III-V and fibronectin, and also activate other proteases, including MMP-1, MMP-7, MMP-8, and MMP-9 Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-3
-
Homo sapiens
MMP-3
-
Homo sapiens
stromelysin-1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000013
-
tissue inhibitor of metalloproteinases 1 catalytic enzyme domain, pH 7.0, 37°C Homo sapiens
0.00000055
-
tissue inhibitor of metalloproteinases 2 catalytic enzyme domain, pH 7.0, 37°C Homo sapiens

General Information

General Information Comment Organism
evolution despite their similar substrate specificities, the stromelysins show differential patterns of transcriptional regulation and tissue distribution that hint at distinct physiological functions in processes such as skeletal development, wound healing, and vascular remodeling Homo sapiens