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Literature summary for 3.4.24.17 extracted from

  • Khaddam, M.; Salmon, B.; Le Denmat, D.; Tjaderhane, L.; Menashi, S.; Chaussain, C.; Rochefort, G.Y.; Boukpessi, T.
    Grape seed extracts inhibit dentin matrix degradation by MMP-3 (2014), Front. Physiol., 5, 425.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.17

Inhibitors

Inhibitors Comment Organism Structure
additional information grapefruit seed extracts inhibit dentin matrix degradation by the enzyme. A grape seed extract mouthrinse and its active components not only have an anti-MMP action but also modify the dentin surface accessibility. The mouthrinse and its active components appear to limit the disorganization inside dentinal tubules induced by the MMP-3 action Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme degrades several dentin matrix proteins, a demineralized and pretreated dentin block is used for activity assays. Enzyme MMP-3 is capable of degrading the protein core of proteoglycans, resulting in the release of soluble glycosaminoglycans ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P08254
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dentin MMP-3 has been identified in predentin and in dentin, where it localizes within the intertubular dentin, along the collagen fibrils Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme degrades several dentin matrix proteins, a demineralized and pretreated dentin block is used for activity assays. Enzyme MMP-3 is capable of degrading the protein core of proteoglycans, resulting in the release of soluble glycosaminoglycans Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MMP-3
-
 Homo sapiens
Proteoglycanase
-
 Homo sapiens
stromelysin-1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Homo sapiens

General Information

General Information Comment Organism
physiological function the enzyme performs dentin matrix degradation Homo sapiens