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Literature summary for 3.4.24.17 extracted from

  • Green, J.A.; Elkington, P.T.; Pennington, C.J.; Roncaroli, F.; Dholakia, S.; Moores, R.C.; Bullen, A.; Porter, J.C.; Agranoff, D.; Edwards, D.R.; Friedland, J.S.
    Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and activator protein-1-dependent monocyte networks (2010), J. Immunol., 184, 6492-6503.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
TIMP-1 determination in cell culture medium Homo sapiens
TIMP-2 determination in cell culture medium Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted, determination of MMP-3 in cell culture medium Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain in the center of granulomas Homo sapiens
-
cell culture
-
Homo sapiens
-
central nervous system
-
Homo sapiens
-
microglia
-
Homo sapiens
-
monocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
casein + H2O casein zymography assay method Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
matrix metalloproteinase-3
-
Homo sapiens
MMP-3
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens dexamethasone suppression of MMP-3 gene expression down
Homo sapiens TNF-alpha and interleukin-1beta act synergistically to drive MMP-3 secretion. NF-kappaB and AP-1 c-Jun/FosB heterodimers regulate CoMTb-induced MMP-3 secretion. NF-kappaB p65 and AP-1 c-Jun subunits are upregulated in biopsy granulomas from patients with cerebral tuberculosis. CoMTb upregulates MMP-3 gene expression and secretion in microglia up

General Information

General Information Comment Organism
physiological function inflammatory tissue destruction is central to pathology in cerebral tuberculosis with microglial-derived matrix metalloproteinases playing a key role in driving such damage Homo sapiens