Inhibitors | Comment | Organism | Structure |
---|---|---|---|
TIMP-1 | determination in cell culture medium | Homo sapiens | |
TIMP-2 | determination in cell culture medium | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted, determination of MMP-3 in cell culture medium | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | in the center of granulomas | Homo sapiens | - |
cell culture | - |
Homo sapiens | - |
central nervous system | - |
Homo sapiens | - |
microglia | - |
Homo sapiens | - |
monocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
casein + H2O | casein zymography assay method | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
matrix metalloproteinase-3 | - |
Homo sapiens |
MMP-3 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | dexamethasone suppression of MMP-3 gene expression | down |
Homo sapiens | TNF-alpha and interleukin-1beta act synergistically to drive MMP-3 secretion. NF-kappaB and AP-1 c-Jun/FosB heterodimers regulate CoMTb-induced MMP-3 secretion. NF-kappaB p65 and AP-1 c-Jun subunits are upregulated in biopsy granulomas from patients with cerebral tuberculosis. CoMTb upregulates MMP-3 gene expression and secretion in microglia | up |
General Information | Comment | Organism |
---|---|---|
physiological function | inflammatory tissue destruction is central to pathology in cerebral tuberculosis with microglial-derived matrix metalloproteinases playing a key role in driving such damage | Homo sapiens |