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Literature summary for 3.4.24.17 extracted from

  • Whitlock, G.A.; Dack. K.N.; Dickinson, R.P.; Lewis M.L
    A novel series of highly selective inhibitors of MMP-3 (2007), Bioorg. Med. Chem. Lett., 17, 6750-6753.
    View publication on PubMed
Search for more literature for 3.4.24.17

Application

Application Comment Organism
medicine topical treatment of chronic dermal ulcers Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-([4-[3'-(2-aminoethoxy)-2-methylbiphenyl-4-yl]piperidin-1-yl]sulfonyl)-N-hydroxy-2-methylpropanamide
-
 Homo sapiens
2-[(2-biphenyl-4-ylethyl)(methyl)sulfamoyl]-N-hydroxyacetamide
-
 Homo sapiens
2-[(3-biphenyl-4-ylazetidin-1-yl)sulfonyl]-N-hydroxyacetamide
-
 Homo sapiens
2-[(3-biphenyl-4-ylpropyl)(methyl)sulfamoyl]-N-hydroxyacetamide
-
 Homo sapiens
2-[(4-biphenyl-4-yl-3,6-dihydropyridin-1(2H)-yl)sulfonyl]-N-hydroxyacetamide
-
 Homo sapiens
2-[(4-biphenyl-4-ylpiperidin-1-yl)sulfonyl]-N-hydroxyacetamide
-
 Homo sapiens
2-[(4-[3'-[2-(dimethylamino)ethoxy]-2-methylbiphenyl-4-yl]piperidin-1-yl)sulfonyl]-N-hydroxy-2-methylpropanamide
-
 Homo sapiens
2-[(biphenyl-4-ylmethyl)(methyl)sulfamoyl]-N-hydroxyacetamide
-
 Homo sapiens
2-[[3-(biphenyl-4-yloxy)azetidin-1-yl]sulfonyl]-N-hydroxyacetamide
-
 Homo sapiens
2-[[4-(2,3'-dimethylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide
-
 Homo sapiens
2-[[4-(2-chlorobiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide
-
 Homo sapiens
2-[[4-(2-ethylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide
-
 Homo sapiens
2-[[4-(2-fluorobiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide
-
 Homo sapiens
2-[[4-(3'-ethoxy-2-methylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide
-
 Homo sapiens
2-[[4-(3'-ethoxy-2-methylbiphenyl-4-yl)piperidin-1-yl]sulfonyl]-N-hydroxy-2-methylpropanamide
-
 Homo sapiens
2-[[4-(3'-ethyl-2-methylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide
-
 Homo sapiens
N-hydroxy-2-([4-[2-(trifluoromethyl)biphenyl-4-yl]-3,6-dihydropyridin-1(2H)-yl]sulfonyl)acetamide
-
 Homo sapiens
N-hydroxy-2-([4-[2-methyl-3'-(trifluoromethoxy)biphenyl-4-yl]-3,6-dihydropyridin-1(2H)-yl]sulfonyl)acetamide
-
 Homo sapiens
N-hydroxy-2-([4-[3'-(2-hydroxyethoxy)-2-methylbiphenyl-4-yl]piperidin-1-yl]sulfonyl)-2-methylpropanamide
-
 Homo sapiens
N-hydroxy-2-([4-[3'-(2-methoxyethoxy)-2-methylbiphenyl-4-yl]piperidin-1-yl]sulfonyl)-2-methylpropanamide
-
 Homo sapiens
N-hydroxy-2-([4-[3'-(methoxymethyl)-2-methylbiphenyl-4-yl]-3,6-dihydropyridin-1(2H)-yl]sulfonyl)acetamide
-
 Homo sapiens
N-hydroxy-2-methyl-2-[(4-[2-methyl-3'-[2-(methylamino)ethoxy]biphenyl-4-yl]piperidin-1-yl)sulfonyl]propanamide
-
 Homo sapiens
N-hydroxy-2-[(4-[4-[6-(2-hydroxyethoxy)pyridin-2-yl]-3-methylphenyl]piperidin-1-yl)sulfonyl]-2-methylpropanamide
-
 Homo sapiens
N-hydroxy-2-[[4-(2-methylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]acetamide
-
 Homo sapiens
N-hydroxy-2-[[4-(3'-methoxy-2-methylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]acetamide
-
 Homo sapiens
N-hydroxy-2-[[4-(4-phenoxyphenyl)piperidin-1-yl]sulfonyl]acetamide
-
 Homo sapiens
UK-370106
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
MMP-3
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000003
-
-
 Homo sapiens N-hydroxy-2-methyl-2-[(4-[2-methyl-3'-[2-(methylamino)ethoxy]biphenyl-4-yl]piperidin-1-yl)sulfonyl]propanamide
0.0000004
-
-
 Homo sapiens 2-([4-[3'-(2-aminoethoxy)-2-methylbiphenyl-4-yl]piperidin-1-yl]sulfonyl)-N-hydroxy-2-methylpropanamide
0.000001
-
-
 Homo sapiens 2-[(4-[3'-[2-(dimethylamino)ethoxy]-2-methylbiphenyl-4-yl]piperidin-1-yl)sulfonyl]-N-hydroxy-2-methylpropanamide
0.000001
-
-
 Homo sapiens N-hydroxy-2-([4-[3'-(2-hydroxyethoxy)-2-methylbiphenyl-4-yl]piperidin-1-yl]sulfonyl)-2-methylpropanamide
0.000001
-
-
 Homo sapiens N-hydroxy-2-[(4-[4-[6-(2-hydroxyethoxy)pyridin-2-yl]-3-methylphenyl]piperidin-1-yl)sulfonyl]-2-methylpropanamide
0.000002
-
-
 Homo sapiens 2-[[4-(3'-ethoxy-2-methylbiphenyl-4-yl)piperidin-1-yl]sulfonyl]-N-hydroxy-2-methylpropanamide
0.000003
-
-
 Homo sapiens 2-[[4-(2-fluorobiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide
0.000003
-
-
 Homo sapiens N-hydroxy-2-([4-[3'-(2-methoxyethoxy)-2-methylbiphenyl-4-yl]piperidin-1-yl]sulfonyl)-2-methylpropanamide
0.000003
-
-
 Homo sapiens N-hydroxy-2-([4-[3'-(methoxymethyl)-2-methylbiphenyl-4-yl]-3,6-dihydropyridin-1(2H)-yl]sulfonyl)acetamide
0.000004
-
-
 Homo sapiens 2-[[4-(2,3'-dimethylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide
0.000004
-
-
 Homo sapiens 2-[[4-(3'-ethoxy-2-methylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide
0.000005
-
-
 Homo sapiens N-hydroxy-2-[[4-(3'-methoxy-2-methylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]acetamide
0.000006
-
-
 Homo sapiens 2-[(4-biphenyl-4-yl-3,6-dihydropyridin-1(2H)-yl)sulfonyl]-N-hydroxyacetamide
0.000016
-
-
 Homo sapiens N-hydroxy-2-[[4-(2-methylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]acetamide
0.000023
-
-
 Homo sapiens UK-370106
0.000026
-
-
 Homo sapiens 2-[(4-biphenyl-4-ylpiperidin-1-yl)sulfonyl]-N-hydroxyacetamide
0.000031
-
-
 Homo sapiens 2-[[4-(3'-ethyl-2-methylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide
0.000051
-
-
 Homo sapiens N-hydroxy-2-([4-[2-methyl-3'-(trifluoromethoxy)biphenyl-4-yl]-3,6-dihydropyridin-1(2H)-yl]sulfonyl)acetamide
0.000055
-
-
 Homo sapiens 2-[[4-(2-chlorobiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide
0.000084
-
-
 Homo sapiens 2-[[3-(biphenyl-4-yloxy)azetidin-1-yl]sulfonyl]-N-hydroxyacetamide
0.000161
-
-
 Homo sapiens 2-[(3-biphenyl-4-ylazetidin-1-yl)sulfonyl]-N-hydroxyacetamide
0.000164
-
-
 Homo sapiens 2-[(2-biphenyl-4-ylethyl)(methyl)sulfamoyl]-N-hydroxyacetamide
0.000174
-
-
 Homo sapiens 2-[(3-biphenyl-4-ylpropyl)(methyl)sulfamoyl]-N-hydroxyacetamide
0.000205
-
-
 Homo sapiens N-hydroxy-2-[[4-(4-phenoxyphenyl)piperidin-1-yl]sulfonyl]acetamide
0.000378
-
-
 Homo sapiens 2-[(biphenyl-4-ylmethyl)(methyl)sulfamoyl]-N-hydroxyacetamide
0.000402
-
-
 Homo sapiens 2-[[4-(2-ethylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide
0.00096
-
-
 Homo sapiens N-hydroxy-2-([4-[2-(trifluoromethyl)biphenyl-4-yl]-3,6-dihydropyridin-1(2H)-yl]sulfonyl)acetamide