Application | Comment | Organism |
---|---|---|
medicine | proteolytic activity of the enzyme is precisely regulated by endogenous tissue inhibitors, disruption of this balance results in diseases such as arthritis, atherosclerosis, tumour growth and metastasis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
selenomethionine-substituted C-terminally truncated proMMP-3(DELTAC) expressed in Escherichia coli B834(DE3) | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
selenomethionine-substituted C-terminally truncated proMMP-3(DELTAC), sitting drop vapour-diffusion technique, crystals belong to tetragonal space group P4(3), cell axes a = b = 80.62 A, c = 157.62 A | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
TIMP-1 | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc endopeptidase | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | required for the degradation of extracellular matrix components during normal embryo development, morphogenesis and tissue remodelling | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
human | - |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | required for the degradation of extracellular matrix components during normal embryo development, morphogenesis and tissue remodelling | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MMP-3 | - |
Homo sapiens |
stromelysin-1 | - |
Homo sapiens |