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Literature summary for 3.4.24.17 extracted from
- Three-dimensional quantitative structure-activity relationship (3D-QSAR) models for a novel class of piperazine-based stromelysin-1 (MMP-3) inhibitors: applying a "divide and conquer" strategy (2001), J. Med. Chem., 44, 3849-3855.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | MMP proteolysis contributes to tissue degeneration and inflammation in osteo and rheumatoid arthritis and may also play a role in the spread of such diseases, abnormally high concentrations of MMPs have been identified in human tissue surrounding invasive carcinomas, indicating a local imbalance in the MMP-TIMP equilibrium which directly enables tumor metastasis through EMP degradation and blood vessel formation | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| amide substituted piperazine-based MMP inhibitor | - |
Homo sapiens | |
| N-alkyl-and heterocycle-substitited piperazine-based MMP inhibitor | - |
Homo sapiens | |
| sulfonamide-and carbamide substituted piperazine-based MMP inhibitor | - |
Homo sapiens | |
| urea substituted piperazine-based MMP inhibitor | - |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MMP-3 | - |
Homo sapiens |
| stromelysin-1 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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