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Literature summary for 3.4.24.16 extracted from

  • Rashid, M.; Wangler, N.J.; Yang, L.; Shah, K.; Arumugam, T.V.; Abbruscato, T.J.; Karamyan, V.T.
    Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain (2014), J. Neurochem., 129, 179-189.
    View publication on PubMed
Search for more literature for 3.4.24.16

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-bound endopeptidase Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
angiotensin I + H2O Mus musculus
-
 ?
-
 ?
angiotensin II + H2O Mus musculus
-
 ?
-
 ?
bradykinin + H2O Mus musculus
-
 ?
-
 ?
dynorphin A(1-8) + H2O Mus musculus
-
 ?
-
 ?
hemopressin + H2O Mus musculus
-
 ?
-
 ?
metorphamide + H2O Mus musculus
-
 ?
-
 ?
neurotensin + H2O Mus musculus
-
 ?
-
 ?
somatostatin + H2O Mus musculus
-
 ?
-
 ?
Substance P + H2O Mus musculus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain membrane preparations of frontoparietal cortex, striatum, and hippocampus isolated from the ischemic hemisphere of mouse brain 24 h after reperfusion reveal a statistically significant over 2fold increase in quantity and activity of neurolysin compared with sham-operated controls, no effect on the cerebellar enzyme activity. Functional up-regulation of neurolysin in frontoparietal cortical membranes for at least 7 days after stroke appears not to be transcriptionally or translationally regulated, but rather depends on translocation of cytosolic neurolysin to the membranes and mitochondria Mus musculus
-
corpus striatum
-
 Mus musculus
-
frontoparietal cortex
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
angiotensin I + H2O
-
 Mus musculus ?
-
 ?
angiotensin II + H2O
-
 Mus musculus ?
-
 ?
bradykinin + H2O
-
 Mus musculus ?
-
 ?
dynorphin A(1-8) + H2O
-
 Mus musculus ?
-
 ?
hemopressin + H2O
-
 Mus musculus ?
-
 ?
metorphamide + H2O
-
 Mus musculus ?
-
 ?
neurotensin + H2O
-
 Mus musculus ?
-
 ?
somatostatin + H2O
-
 Mus musculus ?
-
 ?
Substance P + H2O
-
 Mus musculus ?
-
 ?

Expression

Organism Comment Expression
Mus musculus membrane-bound endopeptidase neurolysin is up-regulated in different parts of mouse brain affected by focal ischemia-reperfusion in a middle cerebral artery occlusion model of stroke, up-regulation of neurolysin occurs in post-ischemic brain regions up

General Information

General Information Comment Organism
physiological function the enzyme is involved in peptidergic systems that play a role in pathogenesis of stroke and resistance to ischemic injury and/or post-stroke brain recovery. Neurolysin may play a role in processes modulating the brain's response to stroke and its recovery after stroke Mus musculus