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Literature summary for 3.4.24.16 extracted from

  • Vincent, B.; Beaudet, A.; Dauch, P.; Vincent, J.P.; Checler, F.
    Distinct properties of neuronal and astrocytic endopeptidase 3.4.24.16: a study on differentiation, subcellular distribution, and secretion processes (1996), J. Neurosci., 16, 5049-5059.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
membrane the membrane-associated enzyme form increases during neuronal differentation and appears to be responsible for the overall augmentation of endopeptidase activity observed during neuronal maturation Mus musculus 16020
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soluble the enzyme secreted from astrocytes would act in the extracellular space, thereby restricting diffusion of released neurotensin Mus musculus
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme secreted from astrocytes would act in the extracellular space, thereby restricting diffusion of released neurotensin. The neuronal membrane-associated activity would be responsible for the physiological inactivation of the peptide either in the synaptic cleft, beside the neurotensin receptors, or inside early endosomal compartments in which receptor-ligand complexes would have been internalized ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte contain only soluble enzyme Mus musculus
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neuron contains both soluble and membrane-associated enzyme Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme secreted from astrocytes would act in the extracellular space, thereby restricting diffusion of released neurotensin. The neuronal membrane-associated activity would be responsible for the physiological inactivation of the peptide either in the synaptic cleft, beside the neurotensin receptors, or inside early endosomal compartments in which receptor-ligand complexes would have been internalized Mus musculus ?
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 ?