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Literature summary for 3.4.24.16 extracted from
- Peripheral inactivation of neurotensin. Isolation and characterization of a metallopeptidase from rat ileum (1988), Eur. J. Biochem., 175, 481-489.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Rattus norvegicus |  |
| acetyl-neurotensin(8-13) | degradation of tritiated neurotensin | Rattus norvegicus | |
| acetyl-neurotensin(8-13)aminde | degradation of tritiated neurotensin | Rattus norvegicus | |
| carboxy-2-phenylethyl-Ala-Ala-Phe-4-aminobenzoate | - |
Rattus norvegicus | |
| Co2+ | - |
Rattus norvegicus | |
| Cu2+ | - |
Rattus norvegicus | |
| dithiothreitol | - |
Rattus norvegicus | |
| EDTA | reactivation by Zn2+ | Rattus norvegicus | |
| neurotensin | inhibits degradation of tritiated neurotensin | Rattus norvegicus | |
| neurotensin(8-13) | degradation of tritiated neurotensin | Rattus norvegicus | |
| neurotensin(9-13) | - |
Rattus norvegicus | |
| Pro-Xaa dipeptides | most potent inhibitors, Xaa-Pro dipeptides are ineffective | Rattus norvegicus | |
| Zn2+ | - |
Rattus norvegicus | |
| [acetylPhe12]neurotensin(8-13) | degradation of tritiated neurotensin | Rattus norvegicus | |
| [Ala12]neurotensin(8-13) | degradation of tritiated neurotensin | Rattus norvegicus | |
| [Ala13]neurotensin(8-13) | degradation of tritiated neurotensin | Rattus norvegicus | |
| [D-Arg8]neurotensin(8-13) | degradation of tritiated neurotensin | Rattus norvegicus | |
| [D-Arg9]neurotensin(8-13) | degradation of tritiated neurotensin | Rattus norvegicus | |
| [D-Leu11]neurotensin | degradation of tritiated neurotensin | Rattus norvegicus | |
| [D-Phe11]neurotensin | degradation of tritiated neurotensin | Rattus norvegicus | |
| [D-Trp11]neurotensin | degradation of tritiated neurotensin | Rattus norvegicus | |
| [D-Tyr11]neurotensin | degradation of tritiated neurotensin | Rattus norvegicus | |
| [D-Tyr3]neurotensin | degradation of tritiated neurotensin | Rattus norvegicus | |
| [Dopa11]neurotensin | degradation of tritiated neurotensin | Rattus norvegicus | |
| [His11]neurotensin | degradation of tritiated neurotensin | Rattus norvegicus | |
| [naphthylalanyl11]neurotensin(8-13) | degradation of tritiated neurotensin | Rattus norvegicus | |
| [Phe11]neurotensin | degradation of tritiated neurotensin | Rattus norvegicus | |
| [Ser11]neurotensin(8-13) | degradation of tritiated neurotensin | Rattus norvegicus | |
| [Thr11]neurotensin | degradation of tritiated neurotensin | Rattus norvegicus | |
| [Trp11]neurotensin | degradation of tritiated neurotensin | Rattus norvegicus | |
| [Tyr-ethyl ester11]neurotensin(8-13) | degradation of tritiated neurotensin | Rattus norvegicus | |
| [Tyr13]neurotensin(8-13) | degradation of tritiated neurotensin | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 70000 | 75000 | gel filtration | Rattus norvegicus |
| 75000 | - |
1 * 75000, SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ileum | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.104 | - |
- |
Rattus norvegicus |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 75000, SDS-PAGE | Rattus norvegicus |
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