Literature summary for 3.4.24.14 extracted from

Dubail, J.; Kesteloot, F.; Deroanne, C.; Motte, P.; Lambert, V.; Rakic, J.M.; Lapiere, C.; Nusgens, B.; Colige, A.
ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule independently of its catalytic activity (2010), Cell. Mol. Life Sci., 67, 4213-4232.

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Cloned(Commentary)

Cloned (Comment)	Organism
recombinant bovine ADAMTS-2 is produced in HEK 293-EBNA cells	Bos taurus

Protein Variants

Protein Variants	Comment	Organism
additional information	three constructs coding for catalytically inactive ADAMTS-2 or for ADAMTS-2 lacking either the central or the C-terminal domains are created and used for stable transfection of HEK 293-EBNA cells. Results show that the catalytic activity of ADAMTS-2 is dispensable for antiangiogenic activity	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Synonyms

Synonyms	Comment	Organism
ADAMTS-2	-	Bos taurus

General Information

General Information	Comment	Organism
malfunction	an anti-tumoral activity is also observed when using cells expressing recombinant deleted forms of ADAMTS-2, including catalytically inactive enzyme	Bos taurus
physiological function	ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule independently of its catalytic activity	Bos taurus

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Release 2023.1 (January 2023)