Application | Comment | Organism |
---|---|---|
additional information | ADAMTS2 diplays procollagen III N-endopeptidase activity, proteolytic processing of ADAMTS2 may generate fragments displaying specifically either procollagen I/II or procollagen III N-endopeptidase acitvity | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
metal chelator | potent inhibitor | Bos taurus | |
additional information | not inhibited by serine protease inhibitors, lysine or serum | Bos taurus | |
Reducing agent | potent inhibitor | Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required for activity | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
72000 | - |
gel filtration | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
400-6000fold purified by ammonium sulfate precipitation, concanavalin A and heparin-Sepharose chromatography and affinity chromatography | Bos taurus |
partially purified | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aortic smooth muscle | - |
Bos taurus | - |
fibroblast | - |
Bos taurus | - |
placenta | - |
Homo sapiens | - |
skin | - |
Bos taurus | - |
tendon | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | no cleavage of heat-denatured procollagen III | Bos taurus | ? | - |
? | |
procollagen I + H2O | processing of either type I/II or type III procollagen | Bos taurus | pCCollagen I + oligopeptide | - |
? | |
procollagen II + H2O | - |
Bos taurus | pCCollagen II + oligopeptide | - |
? | |
procollagen III + H2O | removes the N-terminal propeptide from the native procollagen III, ADAMTS2 purified from skin is unable to process type III procollagen despite its activity on type I procollagen | Bos taurus | pCCollagen III + oligopeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAMTS2 | - |
Homo sapiens |
ADAMTS2 | - |
Bos taurus |
procollagen III N-endopeptidase | - |
Homo sapiens |
procollagen III N-endopeptidase | - |
Bos taurus |
procollagen III N-proteinase | - |
Homo sapiens |
procollagen III N-proteinase | - |
Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Bos taurus |