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Literature summary for 3.4.24.14 extracted from

  • Colige, A.
    Procollagen III N-proteinase (2004), Handbook of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press, 1, 458-460.
No PubMed abstract available

Application

Application Comment Organism
additional information ADAMTS2 diplays procollagen III N-endopeptidase activity, proteolytic processing of ADAMTS2 may generate fragments displaying specifically either procollagen I/II or procollagen III N-endopeptidase acitvity Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
metal chelator potent inhibitor Bos taurus
additional information not inhibited by serine protease inhibitors, lysine or serum Bos taurus
Reducing agent potent inhibitor Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for activity Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
72000
-
gel filtration Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
400-6000fold purified by ammonium sulfate precipitation, concanavalin A and heparin-Sepharose chromatography and affinity chromatography Bos taurus
partially purified Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
aortic smooth muscle
-
Bos taurus
-
fibroblast
-
Bos taurus
-
placenta
-
Homo sapiens
-
skin
-
Bos taurus
-
tendon
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no cleavage of heat-denatured procollagen III Bos taurus ?
-
?
procollagen I + H2O processing of either type I/II or type III procollagen Bos taurus pCCollagen I + oligopeptide
-
?
procollagen II + H2O
-
Bos taurus pCCollagen II + oligopeptide
-
?
procollagen III + H2O removes the N-terminal propeptide from the native procollagen III, ADAMTS2 purified from skin is unable to process type III procollagen despite its activity on type I procollagen Bos taurus pCCollagen III + oligopeptide
-
?

Synonyms

Synonyms Comment Organism
ADAMTS2
-
Homo sapiens
ADAMTS2
-
Bos taurus
procollagen III N-endopeptidase
-
Homo sapiens
procollagen III N-endopeptidase
-
Bos taurus
procollagen III N-proteinase
-
Homo sapiens
procollagen III N-proteinase
-
Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Bos taurus