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Literature summary for 3.4.24.14 extracted from

  • Wang, W.M.; Ge, G.; Lim, N.H.; Nagase, H.; Greenspan, D.S.
    TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2 (2006), Biochem. J., 398, 515-519.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.14

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by TIMP-1, TIMP-2 and TIMP-4 Homo sapiens
TIMP-3 inhibits ADAMTS-2 in vitro in the presence of procollagen I and II, addition of heparin enhances the ability of TIMP-3 to inhibit the enzyme Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
118000
-
 immunoprecipitation, truncated form Homo sapiens
132000
-
 immunoprecipitation, full-length mature form Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procollagen I + H2O
-
 Homo sapiens pCCollagen I + oligopeptide
-
 ?
procollagen II + H2O
-
 Homo sapiens pCCollagen II + oligopeptide
-
 ?

Synonyms

Synonyms Comment Organism
ADAMTS-2
-
 Homo sapiens
procollagen N-proteinase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.16
-
 TIMP-3 in the presence of heparin Homo sapiens
0.602
-
 TIMP-3 in the absence of heparin Homo sapiens