Application | Comment | Organism |
---|---|---|
medicine | disintegrins found in Crotalus atrox venom may have therapeutic potential for reducing hemorrhagic transformation after ischemic stroke | Crotalus atrox |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition by batimastat and prinomastat | Crotalus atrox |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Crotalus atrox | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crotalus atrox | P68520 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | several isoforms of disintegrin Crotatroxi | Crotalus atrox | - |
Synonyms | Comment | Organism |
---|---|---|
Crotatroxin | - |
Crotalus atrox |
disintegrin | - |
Crotalus atrox |
snake venom disintegrin | - |
Crotalus atrox |
General Information | Comment | Organism |
---|---|---|
physiological function | disintegrin Crotatroxin from venom of Crotalus atrox has targets within the coagulation cascade, including receptors on platelets. The disintegrin from venom can attenuates hemorrhagic transformation by preventing activation of matrix metalloproteinase-9 after middle cerebral artery occlusion (MCAO) in hyperglycemic male Sprague-Dawley rats | Crotalus atrox |