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Literature summary for 3.4.23.B9 extracted from
- Bovine leukemia virus protease: comparison with human T-lymphotropic virus and human immunodeficiency virus proteases (2007), J. Gen. Virol., 88, 2052-2063.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| DTT | assay with | bovine leukemia virus |  |
| EDTA | assay with | bovine leukemia virus | |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| N38D | Km: 0.18 mM (KTKVLVVQPK), kcat: 0.023/sec (KTKVLVVQPK) | bovine leukemia virus |
| V57I | Km: 0.0075 mM (KTKVLVVQPK), kcat: 0.006/sec (KTKVLVVQPK) | bovine leukemia virus |
| V57I/L58G/A60I | Km: 0.03 mM (KTKVLVVQPK), kcat: 0.016/sec (KTKVLVVQPK) | bovine leukemia virus |
| W99V | Km: 0.006 mM (KTKVLVVQPK), kcat: 0.003/sec (KTKVLVVQPK) | bovine leukemia virus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ala-Pro-Gln-Val-Leu-r-Pro-Val-Met-His-Pro | - |
bovine leukemia virus | |
| Ala-Pro-Gln-Val-Sta-Val-Met-His-Pro | - |
bovine leukemia virus | |
| amprenavir | - |
bovine leukemia virus | |
| DMP-323 | - |
bovine leukemia virus | |
| HBY-793 | a compound which inhibits EIAV PR | bovine leukemia virus | |
| indinavir | - |
bovine leukemia virus | |
| KH 164 | modest inhibitor of MMLV PR | bovine leukemia virus | |
| LP-149 | inhibitor of FIV PR | bovine leukemia virus | |
| Lys-Thr-Lys-Val-Leu-r-Val-Val-Gln-Pro-Lys | - |
bovine leukemia virus | |
| Lys-Thr-Lys-Val-Sta-Val-Gln-Pro-Gly | - |
bovine leukemia virus | |
| nelfinavir | - |
bovine leukemia virus | |
| ritonavir | - |
bovine leukemia virus | |
| saquinavir | - |
bovine leukemia virus | |
| UK 88.947 | a compound which inhibits HIV-1PR | bovine leukemia virus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.006 | - |
KTKVLVVQPK | value below 0.006, mutant W99V | bovine leukemia virus | |
| 0.0075 | - |
KTKVLVVQPK | mutant V57I | bovine leukemia virus | |
| 0.01 | - |
TKVLVVQPK | - |
bovine leukemia virus | |
| 0.01 | - |
KTKVAVVQPK | P1-substituted peptide | bovine leukemia virus | |
| 0.01 | - |
KTKVLFVQPK | value below 0.01, P1'-substituted peptide | bovine leukemia virus | |
| 0.01 | - |
KTKVGVVQPK | value below 0.01, P1-substituted peptide | bovine leukemia virus | |
| 0.01 | - |
KTKILVVQPK | value below 0.01, P2-substituted peptide | bovine leukemia virus | |
| 0.01 | - |
KTAVLVVQPK | value below 0.01, P3-substituted peptide | bovine leukemia virus | |
| 0.01 | - |
KTSVLVVQPK | value below 0.01, P3-substituted peptide | bovine leukemia virus | |
| 0.01 | - |
KTLVLVVQPK | value below 0.01, P3-substituted peptide | bovine leukemia virus | |
| 0.01 | - |
KTVVLVVQPK | value below 0.01, P3-substituted peptide | bovine leukemia virus | |
| 0.01 | - |
KPKVLVVQPK | value below 0.01, P4-substituted peptide | bovine leukemia virus | |
| 0.01 | - |
KVKVLVVQPK | value below 0.01, P4-substituted peptide | bovine leukemia virus | |
| 0.011 | - |
KTKVLVVQPK | - |
bovine leukemia virus | |
| 0.014 | - |
KTKVYVVQPK | P1-substituted peptide | bovine leukemia virus | |
| 0.015 | - |
KVLVVQPK | - |
bovine leukemia virus | |
| 0.016 | - |
KTKVLSVQPK | P1'-substituted peptide | bovine leukemia virus | |
| 0.017 | - |
KTKVSVVQPK | P1-substituted peptide | bovine leukemia virus | |
| 0.02 | - |
KTKVMVVQPK | value below 0.02, P1-substituted peptide | bovine leukemia virus | |
| 0.02 | - |
KTKFLVVQPK | value below 0.02, P2-substituted peptide | bovine leukemia virus | |
| 0.02 | - |
KTKALVVQPK | value below 0.02, P2-substituted peptide | bovine leukemia virus | |
| 0.02 | - |
KTGVLVVQPK | value below 0.02, P3-substituted peptide | bovine leukemia virus | |
| 0.021 | - |
KTKVLIVQPK | P1'-substituted peptide | bovine leukemia virus | |
| 0.021 | - |
KTKVLLVQPK | P1'-substituted peptide | bovine leukemia virus | |
| 0.021 | - |
KTKVLGVQPK | P1'-substituted peptide | bovine leukemia virus | |
| 0.021 | - |
KGKVLVVQPK | P4-substituted peptide | bovine leukemia virus | |
| 0.022 | - |
KSKVLVVQPK | P4-substitutedpeptide | bovine leukemia virus | |
| 0.025 | - |
KTKLLVVQPK | P2-substituted peptide | bovine leukemia virus | |
| 0.026 | - |
KTKSLVVQPK | P2-substituted peptide | bovine leukemia virus | |
| 0.026 | - |
KTDVLVVQPK | P3-substituted peptide | bovine leukemia virus | |
| 0.03 | - |
KTKVLVVQPK | mutant D97T/K98P/W99V | bovine leukemia virus | |
| 0.03 | - |
KLKVLVVQPK | value below 0.03, P4-substituted peptide | bovine leukemia virus | |
| 0.032 | - |
KTKVDVVQPK | P1-substituted peptide | bovine leukemia virus | |
| 0.033 | - |
KTKNLVVQPK | P2-substituted peptide | bovine leukemia virus | |
| 0.042 | - |
KTFVLVVQPK | P3-substituted peptide | bovine leukemia virus | |
| 0.042 | - |
KAKVLVVQPK | P4-substitutedpeptide | bovine leukemia virus | |
| 0.043 | - |
KTKDLVVQPK | P2-substituted peptide | bovine leukemia virus | |
| 0.048 | - |
KTKVFVVQPK | P1-substituted peptide | bovine leukemia virus | |
| 0.048 | - |
KDKVLVVQPK | P4-substitutedpeptide | bovine leukemia virus | |
| 0.063 | - |
KTKVLPVQPK | P1'-substituted peptide | bovine leukemia virus | |
| 0.13 | - |
KTKVLKVQPK | P1'-substituted peptide | bovine leukemia virus | |
| 0.18 | - |
KTKVLVVQPK | mutant N38D | bovine leukemia virus | |
| 0.2 | - |
KTKGLVVQPK | P2-substituted peptide | bovine leukemia virus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| bovine leukemia virus | P10270 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| KAKVLVVQPK + H2O | P4-substituted peptide | bovine leukemia virus | KAKVL + VVQPK | - |
? | |
| KDKVLVVQPK + H2O | P4-substituted peptide | bovine leukemia virus | KDKVL + VVQPK | - |
? | |
| KGKVLVVQPK + H2O | P4-substituted peptide | bovine leukemia virus | KGKVL + VVQPK | - |
? | |
| KLKVLVVQPK + H2O | P4-substituted peptide | bovine leukemia virus | KLKVL + VVQPK | - |
? | |
| KPKVLVVQPK + H2O | P4-substituted peptide | bovine leukemia virus | KPKVL + VVQPK | - |
? | |
| KSKVLVVQPK + H2O | P4-substituted peptide | bovine leukemia virus | KSKVL + VVQPK | - |
? | |
| KTAVLVVQPK + H2O | P3-substituted peptide | bovine leukemia virus | KTGVL + VVQPK | - |
? | |
| KTDVLVVQPK + H2O | P3-substituted peptide | bovine leukemia virus | KTDVL + VVQPK | - |
? | |
| KTFVLVVQPK + H2O | P3-substituted peptide | bovine leukemia virus | KTFVL + VVQPK | - |
? | |
| KTGVLVVQPK + H2O | P3-substituted peptide | bovine leukemia virus | KTGVL + VVQPK | - |
? | |
| KTKALVVQPK + H2O | P2-substituted peptide | bovine leukemia virus | KTKAL + VVQPK | - |
? | |
| KTKDLVVQPK + H2O | P2-substituted peptide | bovine leukemia virus | KTKDL + VVQPK | - |
? | |
| KTKFLVVQPK + H2O | P2-substituted peptide | bovine leukemia virus | KTKFL + VVQPK | - |
? | |
| KTKGLVVQPK + H2O | P2-substituted peptide | bovine leukemia virus | KTKGL + VVQPK | - |
? | |
| KTKILVVQPK + H2O | P2-substituted peptide | bovine leukemia virus | KTKIL + VVQPK | - |
? | |
| KTKLLVVQPK + H2O | P2-substituted peptide | bovine leukemia virus | KTKLL + VVQPK | - |
? | |
| KTKNLVVQPK + H2O | P2-substituted peptide | bovine leukemia virus | KTKNL + VVQPK | - |
? | |
| KTKSLVVQPK + H2O | P2-substituted peptide | bovine leukemia virus | KTKSL + VVQPK | - |
? | |
| KTKVAVVQPK + H2O | P1-substituted peptide | bovine leukemia virus | KTKVA + VVQPK | - |
? | |
| KTKVDVVQPK + H2O | P1-substituted peptide | bovine leukemia virus | KTKVD + VVQPK | - |
? | |
| KTKVFVVQPK + H2O | P1-substituted peptide | bovine leukemia virus | KTKVF + VVQPK | - |
? | |
| KTKVGVVQPK + H2O | P1-substituted peptide | bovine leukemia virus | KTKVG + VVQPK | - |
? | |
| KTKVLDVQPK + H2O | P1'-substituted peptide | bovine leukemia virus | KTKVL + DVQPK | - |
? | |
| KTKVLFVQPK + H2O | P1'-substituted peptide | bovine leukemia virus | KTKVL + FVQPK | - |
? | |
| KTKVLGVQPK + H2O | P1'-substituted peptide | bovine leukemia virus | KTKVL + GVQPK | - |
? | |
| KTKVLIVQPK + H2O | P1'-substituted peptide | bovine leukemia virus | KTKVL + IVQPK | - |
? | |
| KTKVLKVQPK + H2O | P1'-substituted peptide | bovine leukemia virus | KTKVL + KVQPK | - |
? | |
| KTKVLLVQPK + H2O | P1'-substituted peptide | bovine leukemia virus | KTKVL + LVQPK | - |
? | |
| KTKVLPVQPK + H2O | P1'-substituted peptide | bovine leukemia virus | KTKVL + PVQPK | - |
? | |
| KTKVLSVQPK + H2O | P1'-substituted peptide | bovine leukemia virus | KTKVL + SVQPK | - |
? | |
| KTKVLVVQPK + H2O | - |
bovine leukemia virus | KTKVL + VVQPK | - |
? | |
| KTKVMVVQPK + H2O | P1-substituted peptide | bovine leukemia virus | KTKVM + VVQPK | - |
? | |
| KTKVSVVQPK + H2O | P1-substituted peptide | bovine leukemia virus | KTKVS + VVQPK | - |
? | |
| KTKVYVVQPK + H2O | P1-substituted peptide | bovine leukemia virus | KTKVY + VVQPK | - |
? | |
| KTLVLVVQPK + H2O | P3-substituted peptide | bovine leukemia virus | KTLVL + VVQPK | - |
? | |
| KTSVLVVQPK + H2O | P3-substituted peptide | bovine leukemia virus | KTSVL + VVQPK | - |
? | |
| KTVVLVVQPK + H2O | P3-substituted peptide | bovine leukemia virus | KTVVL + VVQPK | - |
? | |
| KVKVLVVQPK + H2O | P4-substituted peptide | bovine leukemia virus | KVKVL + VVQPK | - |
? | |
| KVLVVQPK + H2O | - |
bovine leukemia virus | KVL + VVQPK | - |
? | |
| TKVLVVQPK + H2O | - |
bovine leukemia virus | TKVL + VVQPK | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| bovine leukemia virus protease | - |
bovine leukemia virus |
| BVL PR | - |
bovine leukemia virus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | bovine leukemia virus |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.003 | - |
KTKVLVVQPK | mutant W99V | bovine leukemia virus | |
| 0.006 | - |
KTKVLVVQPK | mutant V57I | bovine leukemia virus | |
| 0.01 | - |
KTKVLDVQPK | value below 0.01, P1'-substituted peptide | bovine leukemia virus | |
| 0.016 | - |
KTKVLVVQPK | mutant D97T/K98P/W99V | bovine leukemia virus | |
| 0.07 | - |
KTKDLVVQPK | P2-substituted peptide | bovine leukemia virus | |
| 0.09 | - |
KTKVGVVQPK | P1-substituted peptide | bovine leukemia virus | |
| 0.11 | - |
KTKVSVVQPK | P1-substituted peptide | bovine leukemia virus | |
| 0.11 | - |
KTKVDVVQPK | P1-substituted peptide | bovine leukemia virus | |
| 0.11 | - |
KTLVLVVQPK | P3-substituted peptide | bovine leukemia virus | |
| 0.12 | - |
KTKVLGVQPK | P1'-substituted peptide | bovine leukemia virus | |
| 0.13 | - |
KTKNLVVQPK | P2-substituted peptide | bovine leukemia virus | |
| 0.13 | - |
KTVVLVVQPK | P3-substituted peptide | bovine leukemia virus | |
| 0.16 | - |
KPKVLVVQPK | P4-substituted peptide | bovine leukemia virus | |
| 0.17 | - |
KTDVLVVQPK | P3-substituted peptide | bovine leukemia virus | |
| 0.18 | - |
KTKVLSVQPK | P1'-substituted peptide | bovine leukemia virus | |
| 0.18 | - |
KTAVLVVQPK | P3-substituted peptide | bovine leukemia virus | |
| 0.19 | - |
KTKGLVVQPK | P2-substituted peptide | bovine leukemia virus | |
| 0.19 | - |
KSKVLVVQPK | P4-substituted peptide | bovine leukemia virus | |
| 0.2 | - |
KTSVLVVQPK | P3-substituted peptide | bovine leukemia virus | |
| 0.2 | - |
KVKVLVVQPK | P4-substituted peptide | bovine leukemia virus | |
| 0.22 | - |
KAKVLVVQPK | P4-substituted peptide | bovine leukemia virus | |
| 0.23 | - |
KTKVLVVQPK | mutant N38D | bovine leukemia virus | |
| 0.23 | - |
KTKVLIVQPK | P1'-substituted peptide | bovine leukemia virus | |
| 0.24 | - |
KTKVMVVQPK | P1-substituted peptide | bovine leukemia virus | |
| 0.27 | - |
KTKVLVVQPK | - |
bovine leukemia virus | |
| 0.28 | - |
KTKVLFVQPK | P1'-substituted peptide | bovine leukemia virus | |
| 0.29 | - |
KTKILVVQPK | P2-substituted peptide | bovine leukemia virus | |
| 0.29 | - |
KTKLLVVQPK | P2-substituted peptide | bovine leukemia virus | |
| 0.32 | - |
KTKFLVVQPK | P2-substituted peptide | bovine leukemia virus | |
| 0.34 | - |
KTKVLLVQPK | P1'-substituted peptide | bovine leukemia virus | |
| 0.34 | - |
KTKVAVVQPK | P1-substituted peptide | bovine leukemia virus | |
| 0.35 | - |
TKVLVVQPK | - |
bovine leukemia virus | |
| 0.35 | - |
KTKALVVQPK | P2-substituted peptide | bovine leukemia virus | |
| 0.35 | - |
KTKSLVVQPK | P2-substituted peptide | bovine leukemia virus | |
| 0.36 | - |
KTKVLKVQPK | P1'-substituted peptide | bovine leukemia virus | |
| 0.44 | - |
KTFVLVVQPK | P3-substituted peptide | bovine leukemia virus | |
| 0.58 | - |
KGKVLVVQPK | P4-substituted peptide | bovine leukemia virus | |
| 0.71 | - |
KVLVVQPK | - |
bovine leukemia virus | |
| 0.74 | - |
KTKVYVVQPK | P1-substituted peptide | bovine leukemia virus | |
| 0.74 | - |
KTGVLVVQPK | P3-substituted peptide | bovine leukemia virus | |
| 0.74 | - |
KLKVLVVQPK | P4-substituted peptide | bovine leukemia virus | |
| 0.85 | - |
KTKVLPVQPK | P1'-substituted peptide | bovine leukemia virus | |
| 0.9 | - |
KDKVLVVQPK | P4-substituted peptide | bovine leukemia virus | |
| 2 | - |
KTKVFVVQPK | P1-substituted peptide | bovine leukemia virus | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.6 | - |
assay at | bovine leukemia virus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.013 | - |
Lys-Thr-Lys-Val-Leu-r-Val-Val-Gln-Pro-Lys | - |
bovine leukemia virus | |
| 0.088 | - |
Ala-Pro-Gln-Val-Leu-r-Pro-Val-Met-His-Pro | - |
bovine leukemia virus | |
| 0.108 | - |
Lys-Thr-Lys-Val-Sta-Val-Gln-Pro-Gly | - |
bovine leukemia virus | |
| 0.114 | - |
amprenavir | - |
bovine leukemia virus | |
| 0.181 | - |
Ala-Pro-Gln-Val-Sta-Val-Met-His-Pro | - |
bovine leukemia virus | |
| 1 | - |
HBY-793 | a compound which inhibits EIAV PR | bovine leukemia virus | |
| 1.715 | - |
KH 164 | modest inhibitor of MMLV PR | bovine leukemia virus | |
| 9.475 | - |
indinavir | - |
bovine leukemia virus | |
| 11.47 | - |
ritonavir | - |
bovine leukemia virus | |
| 12.96 | - |
LP-149 | inhibitor of FIV PR | bovine leukemia virus | |
| 20 | - |
UK 88.947 | a compound which inhibits HIV-1PR | bovine leukemia virus | |
| 20 | - |
saquinavir | value above 20 mM | bovine leukemia virus | |
| 20 | - |
nelfinavir | value above 20 mM | bovine leukemia virus | |
| 20 | - |
DMP-323 | value above 20 mM | bovine leukemia virus | |
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