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Literature summary for 3.4.23.49 extracted from

  • Jaervinen, H.M.; Laakkonen, L.; Haiko, J.; Johansson, T.; Juuti, K.; Suomalainen, M.; Buchrieser, C.; Kalkkinen, N.; Korhonen, T.K.
    Human single-chain urokinase is activated by the omptins PgtE of Salmonella enterica and Pla of Yersinia pestis despite mutations of active site residues (2013), Mol. Microbiol., 89, 507-517.
    View publication on PubMed
Search for more literature for 3.4.23.49

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Escherichia coli
expression in Escherichia coli Salmonella enterica
expression in Escherichia coli Yersinia pestis

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Salmonella enterica
-
-
-
Salmonella enterica 14028R
-
-
-
Yersinia pestis P17811
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human single-chain urokinase + H2O
-
 Escherichia coli ? cleavage at the peptide bond Lys158-Ile159, the site cleaved also by the physiological activator human plasmin ?
human single-chain urokinase + H2O
-
 Salmonella enterica ? cleavage at the peptide bond Lys158-Ile159, the site cleaved also by the physiological activator human plasmin ?
human single-chain urokinase + H2O
-
 Yersinia pestis ? cleavage at the peptide bond Lys158-Ile159, the site cleaved also by the physiological activator human plasmin. Enzyme addtionally displays activity of EC 3.4.23.48 ?
human single-chain urokinase + H2O
-
 Salmonella enterica 14028R ? cleavage at the peptide bond Lys158-Ile159, the site cleaved also by the physiological activator human plasmin ?

Synonyms

Synonyms Comment Organism
OmpP
-
 Escherichia coli
ompT
-
 Escherichia coli
PgtE
-
 Salmonella enterica