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Literature summary for 3.4.23.46 extracted from

  • Chlebek, J.; De Simone, A.; Hostalkova, A.; Opletal, L.; Perez, C.; Perez, D.I.; Havlikova, L.; Cahlikova, L.; Andrisano, V.
    Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimers disease targets (2016), Fitoterapia, 109, 241-247 .
    View publication on PubMed
Search for more literature for 3.4.23.46

Inhibitors

Inhibitors Comment Organism Structure
(+)-canadaline 41.02% inhibition at 0.005 mM Homo sapiens
(+)-corynoline 21.91% inhibition at 0.005 mM Homo sapiens
(+/-)-corycavidine 26.87% inhibition at 0.005 mM Homo sapiens
(-)-corycavamine 34.4% inhibition at 0.005 mM Homo sapiens
(-)-isocorypalmine 26.68% inhibition at 0.005 mM Homo sapiens
(-)-scoulerine 24.34% inhibition at 0.005 mM Homo sapiens
Allocryptopine 26.18% inhibition at 0.005 mM Homo sapiens
additional information not inhibited by 0.005 mM (+)-canadine, (+)-corydaline, (+)-tetrahydropalmatine, (+)-corydine, (+)-bulbocapnine, (+)-corypalmine, (-)-sinoacutine, and (+)-N-methyllaurotetanine Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid-beta precursor protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P56817
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid-beta precursor protein + H2O
-
 Homo sapiens ?
-
 ?
M-2420 + H2O
-
 Homo sapiens ?
-
 ?
rhodamine-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-quencher + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
BACE1
-
 Homo sapiens
beta-site amyloid precursor protein cleaving enzyme 1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.03359
-
 at pH 4.0 and 25°C Homo sapiens (+)-corynoline
0.04116
-
 at pH 4.0 and 25°C Homo sapiens (-)-corycavamine