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Literature summary for 3.4.23.46 extracted from

  • Innocenti, R.; Lenci, E.; Menchi, G.; Pupi, A.; Trabocchi, A.
    Design and synthesis of bicyclic acetals as beta secretase (BACE1) inhibitors (2017), Bioorg. Med. Chem., 25, 5077-5083 .
    View publication on PubMed
Search for more literature for 3.4.23.46

Inhibitors

Inhibitors Comment Organism Structure
(1R,4S,5R,7R)-3,4-dibenzyl-2-oxo-N-(prop-2-yn-1-yl)-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxamide 32% inhibition at 0.01 mM Homo sapiens
(1R,4S,5R,7R)-3,4-dibenzyl-7-(piperidin-1-ylcarbonyl)-6,8-dioxa-3-azabicyclo[3.2.1]octan-2-one 46% inhibition at 0.01 mM Homo sapiens
(1R,5R,7R)-3-benzyl-7-(piperidin-1-ylcarbonyl)-6,8-dioxa-3-azabicyclo[3.2.1]octan-2-one 10% inhibition at 0.01 mM Homo sapiens
(1R,5R,7R)-3-benzyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxamide 8% inhibition at 0.01 mM Homo sapiens
ethyl 4-[[(1R,4S,5R,7R)-3,4-dibenzyl-2-thioxo-6,8-dioxa-3-azabicyclo[3.2.1]oct-7-yl]carbonyl]piperazine-1-carboxylate 9% inhibition at 0.01 mM Homo sapiens
ethyl 4-[[(1R,5R,7R)-3-benzyl-2-thioxo-6,8-dioxa-3-azabicyclo[3.2.1]oct-7-yl]carbonyl]piperazine-1-carboxylate 29% inhibition at 0.01 mM Homo sapiens
methyl (1R,4S,5R,7R)-3,4-dibenzyl-2-thioxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxylate 16% inhibition at 0.01 mM Homo sapiens
methyl (1R,5R,7R)-3-benzyl-2-thioxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxylate 16% inhibition at 0.01 mM Homo sapiens
methyl (1S,4R,5S,7S)-3,4-dibenzyl-2-thioxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxylate 16% inhibition at 0.01 mM Homo sapiens
[(1R,4S,5R,7R)-3,4-dibenzyl-2-thioxo-6,8-dioxa-3-azabicyclo[3.2.1]oct-7-yl](morpholin-4-yl)methanone 61% inhibition at 0.01 mM Homo sapiens
[(1R,5R,7R)-3-benzyl-2-thioxo-6,8-dioxa-3-azabicyclo[3.2.1]oct-7-yl](morpholin-4-yl)methanone 15% inhibition at 0.01 mM Homo sapiens
[(1S,4R,5S,7S)-3,4-dibenzyl-2-thioxo-6,8-dioxa-3-azabicyclo[3.2.1]oct-7-yl](morpholin-4-yl)methanone 5% inhibition at 0.01 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid-beta precursor protein + H2O Homo sapiens
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P56817
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid-beta precursor protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
BACE1
-
 Homo sapiens
beta secretase
-
 Homo sapiens