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Literature summary for 3.4.23.46 extracted from

  • Takasugi, N.; Sasaki, T.; Suzuki, K.; Osawa, S.; Isshiki, H.; Hori, Y.; Shimada, N.; Higo, T.; Yokoshima, S.; Fukuyama, T.; Lee, V.M.; Trojanowski, J.Q.; Tomita, T.; Iwatsubo, T.
    BACE1 activity is modulated by cell-associated sphingosine-1-phosphate (2011), J. Neurosci., 31, 6850-6857.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
sphingoisine-1-phosphate treatment by sphingosine kinase inhibitor, RNA interference knockdown of sphingosine kinase, or overexpression of sphingosine 1-phosphate degrading enzymes decrease BACE1 activity, which reduces amyloid beta production. Sphingosine-1-phosphate specifically binds to full-length BACE1 and increases its proteolytic activity, suggesting that cellular sphingosine 1-phosphate directly modulates BACE1 activity Homo sapiens
sphingosine 1-phosphate treatment by sphingosine kinase inhibitor, RNA interference knockdown of sphingosine kinase, or overexpression of sphingosine 1-phosphate degrading enzymes decrease BACE1 activity, which reduces amyloid beta production. Sphingosine-1-phosphate specifically binds to full-length BACE1 and increases its proteolytic activity, suggesting that cellular sphingosine 1-phosphate directly modulates BACE1 activity Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
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 Homo sapiens
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