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Literature summary for 3.4.23.46 extracted from

  • Chiriano, G.; De Simone, A.; Mancini, F.; Perez, D.I.; Cavalli, A.; Bolognesi, M.L.; Legname, G.; Martinez, A.; Andrisano, V.; Carloni, P.; Roberti, M.
    A small chemical library of 2-aminoimidazole derivatives as BACE-1 inhibitors: Structure-based design, synthesis, and biological evaluation (2012), Eur. J. Med. Chem., 48, 206-213.
    View publication on PubMed
Search for more literature for 3.4.23.46

Inhibitors

Inhibitors Comment Organism Structure
1-(2-chlorobenzyl)-4-(4-(dibenzo[b,d]furan-1-yl)benzyl)-1H-imidazol-2-amine 0.005 mM, 37.8% inhibition. Inhibitor is predicted to be able to cross the blood-brain barrier Homo sapiens
1-(4-fluorobenzyl)-4-((30,50-dimethoxybiphenyl-4-yl)methyl)-1H-imidazol-2-amine 0.005 mM, 40% inhibition. Inhibitor is predicted to be able to cross the blood-brain barrier Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(7-methoxycoumarin-4-yl)acetyl-L-Ser-L-Glu-L-Val-L-Asn-L-Leu-L-Asp-L-Ala-L-Glu-L-Phe-L-Lys-dinitrophenyl + H2O
-
 Homo sapiens ?
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0056
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 1-(4-fluorobenzyl)-4-((30,50-dimethoxybiphenyl-4-yl)methyl)-1H-imidazol-2-amine
0.0059
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 1-(2-chlorobenzyl)-4-(4-(dibenzo[b,d]furan-1-yl)benzyl)-1H-imidazol-2-amine