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Literature summary for 3.4.23.46 extracted from

  • Chen, T.J.; Hung, H.S.; Wang, D.C.; Chen, S.S.
    The protective effect of ROCK inhibitor on aluminum-induced neurotoxicity in rat cortical neurons (2010), Toxicol. Sci., 116, 264-272.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid-beta precursor protein + H2O Rattus norvegicus beta-secretase first cleaves the ectodomain of amyloid-beta precursor protein to generate a membrane-bound fragment fragments of amyloid-beta precursor protein
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebral cortical neuron
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid-beta precursor protein + H2O beta-secretase first cleaves the ectodomain of amyloid-beta precursor protein to generate a membrane-bound fragment Rattus norvegicus fragments of amyloid-beta precursor protein
-
?

Synonyms

Synonyms Comment Organism
BACE1
-
Rattus norvegicus
beta-secretase
-
Rattus norvegicus
beta-site amyloid precursor protein cleaving enzyme
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Rattus norvegicus