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Literature summary for 3.4.23.46 extracted from
- Identification of beta-secretase (BACE1) substrates using quantitative proteomics (2009), PLoS ONE, 4, e8477.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| N-((1S,2R)-1-benzyl-3-cyclopropylamino-2-hydroxy-propyl)-5-(methanesulfonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide | beta-secretase inhibitor IV | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | BACE1 is a transmembrane aspartyl protease with a lumenal active site | Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid -like PROTEIN 2 + H2O | Homo sapiens | - |
? | - |
? | |
| amyloid pbeta A4 protein + H2O | Homo sapiens | - |
? | - |
? | |
| amyloid-like protein 1 + H2O | Homo sapiens | - |
? | - |
? | |
| basigin + H2O | Homo sapiens | - |
? | - |
? | |
| beta-secretase 1 + H2O | Homo sapiens | - |
? | - |
? | |
| BMP and activin membrane-bound inhibitor homolog + H2O | Homo sapiens | - |
? | - |
? | |
| cache domain containing 1 + H2O | Homo sapiens | - |
? | - |
? | |
| carboxypeptidase D + H2O | Homo sapiens | - |
? | - |
? | |
| cation-independent mannose-6-phosphate receptor + H2O | Homo sapiens | - |
? | - |
? | |
| CD166 antigen + H2O | Homo sapiens | - |
? | - |
? | |
| CD276 antigen + H2O | Homo sapiens | - |
? | - |
? | |
| chondroitin sulfate proteoglycan 4 + H2O | Homo sapiens | - |
? | - |
? | |
| contactin-1 + H2O | Homo sapiens | - |
? | - |
? | |
| cysteine-rich motor neuron 1 protein + H2O | Homo sapiens | - |
? | - |
? | |
| desmoglein 2 + H2O | Homo sapiens | - |
? | - |
? | |
| disintegrin and metalloproteinase domain-containing protein 10 + H2O | Homo sapiens | - |
? | - |
? | |
| ephrin type-A receptor 2 + H2O | Homo sapiens | - |
? | - |
? | |
| ephrin type-A receptor 4 + H2O | Homo sapiens | - |
? | - |
? | |
| ephrin type-A receptor 7 + H2O | Homo sapiens | - |
? | - |
? | |
| ephrin-A5 + H2O | Homo sapiens | - |
? | - |
? | |
| glypican-3 + H2O | Homo sapiens | - |
? | - |
? | |
| Golgi apparatus protein 1 + H2O | Homo sapiens | - |
? | - |
? | |
| Golgi phosphoprotein 4 + H2O | Homo sapiens | - |
? | - |
? | |
| hepatocyte growth factor receptor + H2O | Homo sapiens | - |
? | - |
? | |
| HLA class I histocompatibility antigen (combined) + H2O | Homo sapiens | - |
? | - |
? | |
| interleukin-6 receptor beta chain + H2O | Homo sapiens | - |
? | - |
? | |
| Jagged-1 + H2O | Homo sapiens | - |
? | - |
? | |
| Kunitz-type protease inhibitor 2 + H2O | Homo sapiens | - |
? | - |
? | |
| leucin-rich repeats and immunoglobulin-like domains protein 1 + H2O | Homo sapiens | - |
? | - |
? | |
| leucin-rich repeats and immunoglobulin-like domains protein 2 + H2O | Homo sapiens | - |
? | - |
? | |
| leucin-rich repeats and immunoglobulin-like domains protein 3 + H2O | Homo sapiens | - |
? | - |
? | |
| leucine-rich repeat-containing protein 33 + H2O | Homo sapiens | - |
? | - |
? | |
| low-density lipoprotein receptor-related protein 11 + H2O | Homo sapiens | - |
? | - |
? | |
| low-density lipoprotein receptor-related protein 4 + H2O | Homo sapiens | - |
? | - |
? | |
| neogenin + H2O | Homo sapiens | - |
? | - |
? | |
| netrin receptor UNC5C + H2O | Homo sapiens | - |
? | - |
? | |
| neuronal cell adhesion molecule 1 + H2O | Homo sapiens | - |
? | - |
? | |
| neuronal cell adhesion molecule L1 + H2O | Homo sapiens | - |
? | - |
? | |
| peptidyl-glycine alpha-amidating monooxygenase + H2O | Homo sapiens | - |
? | - |
? | |
| plexin domain-containing protein 2 + H2O | Homo sapiens | - |
? | - |
? | |
| podocalyxin-like protein 1 + H2O | Homo sapiens | - |
? | - |
? | |
| poliovirus receptor type I + H2O | Homo sapiens | - |
? | - |
? | |
| protocadherin 21 + H2O | Homo sapiens | - |
? | - |
? | |
| protocadherin 7 + H2O | Homo sapiens | - |
? | - |
? | |
| protocadherin gamma A11 + H2O | Homo sapiens | - |
? | - |
? | |
| protocadherin gamma A5 + H2O | Homo sapiens | - |
? | - |
? | |
| protocadherin gamma A8 + H2O | Homo sapiens | - |
? | - |
? | |
| protocadherin gamma C3 + H2O | Homo sapiens | - |
? | - |
? | |
| protogenin + H2O | Homo sapiens | - |
? | - |
? | |
| receptor protein tyrosine kinase variant EPHB4V1 + H2O | Homo sapiens | - |
? | - |
? | |
| receptor-type tyrosin-protein phosphatase S + H2O | Homo sapiens | - |
? | - |
? | |
| roundabout homolog 1 + H2O | Homo sapiens | - |
? | - |
? | |
| roundabout homolog 2 + H2O | Homo sapiens | - |
? | - |
? | |
| seizure 6-like protein 2 + H2O | Homo sapiens | - |
? | - |
? | |
| semaphorin-4B + H2O | Homo sapiens | - |
? | - |
? | |
| semaphorin-4C + H2O | Homo sapiens | - |
? | - |
? | |
| semaphorin-6A + H2O | Homo sapiens | - |
? | - |
? | |
| semaphorin-6D + H2O | Homo sapiens | - |
? | - |
? | |
| sidekick-1 + H2O | Homo sapiens | - |
? | - |
? | |
| sidekick-2 + H2O | Homo sapiens | - |
? | - |
? | |
| sortilin type I + H2O | Homo sapiens | - |
? | - |
? | |
| sortilin-related receptor type I + H2O | Homo sapiens | - |
? | - |
? | |
| syndecan-4 + H2O | Homo sapiens | - |
? | - |
? | |
| T-cell immunomodulatory protein + H2O | Homo sapiens | - |
? | - |
? | |
| toll-like receptor 9 + H2O | Homo sapiens | - |
? | - |
? | |
| trans-Golgi network integral membrane protein 2 + H2O | Homo sapiens | - |
? | - |
? | |
| transmembrane protein 132A + H2O | Homo sapiens | - |
? | - |
? | |
| tumor necrosis factor receptor superfamily member 21 + H2O | Homo sapiens | - |
? | - |
? | |
| vesicular integral-membrane protein VIP36 + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | - |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293FT cell | - |
Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid -like PROTEIN 2 + H2O | - |
Homo sapiens | ? | - |
? | |
| amyloid pbeta A4 protein + H2O | - |
Homo sapiens | ? | - |
? | |
| amyloid-like protein 1 + H2O | - |
Homo sapiens | ? | - |
? | |
| basigin + H2O | - |
Homo sapiens | ? | - |
? | |
| beta-secretase 1 + H2O | - |
Homo sapiens | ? | - |
? | |
| BMP and activin membrane-bound inhibitor homolog + H2O | - |
Homo sapiens | ? | - |
? | |
| cache domain containing 1 + H2O | - |
Homo sapiens | ? | - |
? | |
| carboxypeptidase D + H2O | - |
Homo sapiens | ? | - |
? | |
| cation-independent mannose-6-phosphate receptor + H2O | - |
Homo sapiens | ? | - |
? | |
| CD166 antigen + H2O | - |
Homo sapiens | ? | - |
? | |
| CD276 antigen + H2O | - |
Homo sapiens | ? | - |
? | |
| chondroitin sulfate proteoglycan 4 + H2O | - |
Homo sapiens | ? | - |
? | |
| contactin-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| cysteine-rich motor neuron 1 protein + H2O | - |
Homo sapiens | ? | - |
? | |
| desmoglein 2 + H2O | - |
Homo sapiens | ? | - |
? | |
| disintegrin and metalloproteinase domain-containing protein 10 + H2O | - |
Homo sapiens | ? | - |
? | |
| ephrin type-A receptor 2 + H2O | - |
Homo sapiens | ? | - |
? | |
| ephrin type-A receptor 4 + H2O | - |
Homo sapiens | ? | - |
? | |
| ephrin type-A receptor 7 + H2O | - |
Homo sapiens | ? | - |
? | |
| ephrin-A5 + H2O | - |
Homo sapiens | ? | - |
? | |
| glypican-3 + H2O | - |
Homo sapiens | ? | - |
? | |
| Golgi apparatus protein 1 + H2O | - |
Homo sapiens | ? | - |
? | |
| Golgi phosphoprotein 4 + H2O | - |
Homo sapiens | ? | - |
? | |
| hepatocyte growth factor receptor + H2O | - |
Homo sapiens | ? | - |
? | |
| HLA class I histocompatibility antigen (combined) + H2O | - |
Homo sapiens | ? | - |
? | |
| interleukin-6 receptor beta chain + H2O | - |
Homo sapiens | ? | - |
? | |
| Jagged-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| Kunitz-type protease inhibitor 2 + H2O | - |
Homo sapiens | ? | - |
? | |
| leucin-rich repeats and immunoglobulin-like domains protein 1 + H2O | - |
Homo sapiens | ? | - |
? | |
| leucin-rich repeats and immunoglobulin-like domains protein 2 + H2O | - |
Homo sapiens | ? | - |
? | |
| leucin-rich repeats and immunoglobulin-like domains protein 3 + H2O | - |
Homo sapiens | ? | - |
? | |
| leucine-rich repeat-containing protein 33 + H2O | - |
Homo sapiens | ? | - |
? | |
| low-density lipoprotein receptor-related protein 11 + H2O | - |
Homo sapiens | ? | - |
? | |
| low-density lipoprotein receptor-related protein 4 + H2O | - |
Homo sapiens | ? | - |
? | |
| neogenin + H2O | - |
Homo sapiens | ? | - |
? | |
| netrin receptor UNC5C + H2O | - |
Homo sapiens | ? | - |
? | |
| neuronal cell adhesion molecule 1 + H2O | - |
Homo sapiens | ? | - |
? | |
| neuronal cell adhesion molecule L1 + H2O | - |
Homo sapiens | ? | - |
? | |
| peptidyl-glycine alpha-amidating monooxygenase + H2O | - |
Homo sapiens | ? | - |
? | |
| plexin domain-containing protein 2 + H2O | - |
Homo sapiens | ? | - |
? | |
| podocalyxin-like protein 1 + H2O | - |
Homo sapiens | ? | - |
? | |
| poliovirus receptor type I + H2O | - |
Homo sapiens | ? | - |
? | |
| protocadherin 21 + H2O | - |
Homo sapiens | ? | - |
? | |
| protocadherin 7 + H2O | - |
Homo sapiens | ? | - |
? | |
| protocadherin gamma A11 + H2O | - |
Homo sapiens | ? | - |
? | |
| protocadherin gamma A5 + H2O | - |
Homo sapiens | ? | - |
? | |
| protocadherin gamma A8 + H2O | - |
Homo sapiens | ? | - |
? | |
| protocadherin gamma C3 + H2O | - |
Homo sapiens | ? | - |
? | |
| protogenin + H2O | - |
Homo sapiens | ? | - |
? | |
| receptor protein tyrosine kinase variant EPHB4V1 + H2O | - |
Homo sapiens | ? | - |
? | |
| receptor-type tyrosin-protein phosphatase S + H2O | - |
Homo sapiens | ? | - |
? | |
| roundabout homolog 1 + H2O | - |
Homo sapiens | ? | - |
? | |
| roundabout homolog 2 + H2O | - |
Homo sapiens | ? | - |
? | |
| seizure 6-like protein 2 + H2O | - |
Homo sapiens | ? | - |
? | |
| semaphorin-4B + H2O | - |
Homo sapiens | ? | - |
? | |
| semaphorin-4C + H2O | - |
Homo sapiens | ? | - |
? | |
| semaphorin-6A + H2O | - |
Homo sapiens | ? | - |
? | |
| semaphorin-6D + H2O | - |
Homo sapiens | ? | - |
? | |
| sidekick-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| sidekick-2 + H2O | - |
Homo sapiens | ? | - |
? | |
| sortilin type I + H2O | - |
Homo sapiens | ? | - |
? | |
| sortilin-related receptor type I + H2O | - |
Homo sapiens | ? | - |
? | |
| syndecan-4 + H2O | - |
Homo sapiens | ? | - |
? | |
| T-cell immunomodulatory protein + H2O | - |
Homo sapiens | ? | - |
? | |
| toll-like receptor 9 + H2O | - |
Homo sapiens | ? | - |
? | |
| trans-Golgi network integral membrane protein 2 + H2O | - |
Homo sapiens | ? | - |
? | |
| transmembrane protein 132A + H2O | - |
Homo sapiens | ? | - |
? | |
| tumor necrosis factor receptor superfamily member 21 + H2O | - |
Homo sapiens | ? | - |
? | |
| vesicular integral-membrane protein VIP36 + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BACE1 | - |
Homo sapiens |
| beta-secretase | - |
Homo sapiens |
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