Literature summary for 3.4.23.46 extracted from

Zhang, C.; Browne, A.; Child, D.; Divito, J.R.; Stevenson, J.A.; Tanzi, R.E.
Loss of function of ATXN1 increases amyloid beta-protein levels by potentiating beta-secretase processing of beta-amyloid precursor protein (2010), J. Biol. Chem., 285, 8515-8526.

Search for more literature for 3.4.23.46

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
amyloid precursor protein + H2O	Homo sapiens	beta-secretase cleavage produces s-amyloid precursor protein-beta and the beta-C-terminal fragment C99. ATXN1 loss of function potentiates BACE1 cleavage of amyloid precursor protein	fragments of amyloid precursor protein	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
H4-APP751 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
amyloid precursor protein + H2O	beta-secretase cleavage produces s-amyloid precursor protein-beta and the beta-C-terminal fragment C99. ATXN1 loss of function potentiates BACE1 cleavage of amyloid precursor protein	Homo sapiens	fragments of amyloid precursor protein	-	?

Synonyms

Synonyms	Comment	Organism
BACE1	-	Homo sapiens
beta-secretase	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)