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Literature summary for 3.4.23.46 extracted from

  • Portelius, E.; Brinkmalm, G.; Tran, A.; Andreasson, U.; Zetterberg, H.; Westman-Brinkmalm, A.; Blennow, K.; Ohrfelt, A.
    Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid (2010), Exp. Neurol., 223, 351-358.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Homo sapiens cleavage by beta-secretase at the N-terminus of the Abeta domain produces a fragment known as soluble beta-amyloid precursor protein and the remaining cell membrane spanning fragment of amyloid precursor protein (C99) fragments of amyloid precursor protein
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O cleavage by beta-secretase at the N-terminus of the Abeta domain produces a fragment known as soluble beta-amyloid precursor protein and the remaining cell membrane spanning fragment of amyloid precursor protein (C99) Homo sapiens fragments of amyloid precursor protein
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?

Synonyms

Synonyms Comment Organism
beta-secretase
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Homo sapiens