Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-3-methyl-5,5-diphenyl-3,5-dihydro-4H-imidazol-4-one | - |
Homo sapiens | |
2-amino-3-methyl-5-(2-methylpyridin-4-yl)-5-[3-(pyridin-3-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | - |
Homo sapiens | |
2-amino-3-methyl-5-(2-methylpyridin-4-yl)-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | - |
Homo sapiens | |
2-amino-3-methyl-5-(pyridin-4-yl)-5-[3-(pyridin-3-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | exhibits modest selectivity (about 8fold) against BACE2 | Homo sapiens | |
2-amino-3-methyl-5-phenyl-5-(pyridin-4-yl)-3,5-dihydro-4H-imidazol-4-one | - |
Homo sapiens | |
2-amino-3-methyl-5-[2-(propan-2-yl)pyridin-4-yl]-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | - |
Homo sapiens | |
2-amino-3-methyl-5-[2-methyl-6-(propan-2-yl)pyridin-4-yl]-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | 24% inhibition at 0.0125 mM | Homo sapiens | |
2-amino-5-(2,6-diethylpyridin-4-yl)-3-methyl-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | - |
Homo sapiens | |
2-amino-5-(2,6-dimethylpyridin-4-yl)-3-methyl-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | - |
Homo sapiens | |
2-amino-5-(2-ethyl-6-methylpyridin-4-yl)-3-methyl-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | 28% inhibition at 0.0125 mM | Homo sapiens | |
2-amino-5-(2-ethylpyridin-4-yl)-3-methyl-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | - |
Homo sapiens | |
2-amino-5-(4-methoxy-3-methylphenyl)-3-methyl-5-[3-(pyridin-3-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | - |
Homo sapiens | |
2-amino-5-(biphenyl-3-yl)-3-methyl-5-(pyridin-4-yl)-3,5-dihydro-4H-imidazol-4-one | - |
Homo sapiens | |
2-amino-5-[3-(2-fluoropyridin-3-yl)phenyl]-5-(4-methoxy-3-methylphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one | - |
Homo sapiens | |
8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Abz-SEVNLDAEFR-Dpa + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE2 | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00014 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Homo sapiens | 2-amino-5-(biphenyl-3-yl)-3-methyl-5-(pyridin-4-yl)-3,5-dihydro-4H-imidazol-4-one | |
0.00048 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Homo sapiens | 2-amino-3-methyl-5-(pyridin-4-yl)-5-[3-(pyridin-3-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | |
0.00077 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Homo sapiens | 2-amino-3-methyl-5,5-diphenyl-3,5-dihydro-4H-imidazol-4-one | |
0.00078 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Homo sapiens | 2-amino-5-[3-(2-fluoropyridin-3-yl)phenyl]-5-(4-methoxy-3-methylphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one | |
0.00079 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Homo sapiens | 2-amino-5-(4-methoxy-3-methylphenyl)-3-methyl-5-[3-(pyridin-3-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | |
0.00102 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Homo sapiens | 2-amino-5-(2-ethylpyridin-4-yl)-3-methyl-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | |
0.00117 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Homo sapiens | 2-amino-3-methyl-5-(2-methylpyridin-4-yl)-5-[3-(pyridin-3-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | |
0.00201 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Homo sapiens | 2-amino-3-methyl-5-phenyl-5-(pyridin-4-yl)-3,5-dihydro-4H-imidazol-4-one | |
0.0022 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Homo sapiens | 2-amino-3-methyl-5-(2-methylpyridin-4-yl)-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | |
0.00613 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Homo sapiens | 2-amino-3-methyl-5-[2-(propan-2-yl)pyridin-4-yl]-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | |
0.0236 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Homo sapiens | 2-amino-5-(2,6-diethylpyridin-4-yl)-3-methyl-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | |
0.0241 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Homo sapiens | 2-amino-5-(2,6-dimethylpyridin-4-yl)-3-methyl-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one | |
0.0383 | - |
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 | Homo sapiens | 8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine |