Literature summary for 3.4.23.46 extracted from

Kihara, T.; Shimmyo, Y.; Akaike, A.; Niidome, T.; Sugimoto, H.
Abeta-induced BACE-1 cleaves N-terminal sequence of mPGES-2 (2010), Biochem. Biophys. Res. Commun., 393, 728-733.

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Inhibitors

Inhibitors	Comment	Organism	Structure
N-((1S,2R)-1-benzyl-3-cyclopropylamino-2-hydroxy-propyl)-5-(methanesulfonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide	beta-secretase inhibitor IV	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
Golgi apparatus	-	Homo sapiens	5794	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
amyloid precursor protein + H2O	Homo sapiens	-	fragments of amyloid precursor protein	-	?
membrane-bound prostaglandin E2 synthase-2 + H2O	Homo sapiens	BACE-1 is involved in the cleavage of membrane-bound prostaglandin E2 synthase-2 in its N-terminal portion, which, in turn, enhances the generation of prostaglandin E2	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
amyloid precursor protein + H2O	-	Homo sapiens	fragments of amyloid precursor protein	-	?
HTARWHLRAQDLHERSAAQLSLSS + H2O	-	Homo sapiens	?	-	?
membrane-bound prostaglandin E2 synthase-2 + H2O	BACE-1 is involved in the cleavage of membrane-bound prostaglandin E2 synthase-2 in its N-terminal portion, which, in turn, enhances the generation of prostaglandin E2	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
BACE-1	-	Homo sapiens
beta-amyloid-converting enzyme-1	-	Homo sapiens
beta-site amyloid precursor protein cleaving enzyme-1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	amyloid beta augments protein levels of BACE-1 through oxidative stress, administration of amyloid beta 1-42 for 48 h significantly increases BACE-1 expression levels, simultaneous administration of ibuprofen or indomethacin (0.01 mM) significantly suppresses amyloid beta 1-42-induced BACE-1 up-regulation (0.005 mM, 48 h) in a concentration-dependent manner	up

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Release 2023.1 (January 2023)