Literature summary for 3.4.23.46 extracted from

Chae, S.S.; Yoo, C.B.; Jo, C.; Yun, S.M.; Jo, S.A.; Koh, Y.H.
Caspases-2 and -8 are involved in the presenilin1/gamma-secretase-dependent cleavage of amyloid precursor protein after the induction of apoptosis (2010), J. Neurosci. Res., 88, 1926-1933.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
amyloid precursor protein + H2O	Homo sapiens	-	C-terminal fragment C99 of amyloid precursor protein + ?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
H4 neuroglioma cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
amyloid precursor protein + H2O	-	Homo sapiens	C-terminal fragment C99 of amyloid precursor protein + ?	-	?

Synonyms

Synonyms	Comment	Organism
BACE1	-	Homo sapiens
beta-amyloid-cleaving enzyme	-	Homo sapiens
beta-secretase	-	Homo sapiens

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Release 2023.1 (January 2023)