Literature summary for 3.4.23.46 extracted from

Ma, L.; Ohyagi, Y.; Miyoshi, K.; Sakae, N.; Motomura, K.; Taniwaki, T.; Furuya, H.; Takeda, K.; Tabira, T.; Kira, J.
Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors (2009), J. Alzheimers Dis., 16, 565-575.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	in presenilin 1 mutants I143T or G384A after treatment with apoptosis-inducing agents, increasing levels of p53 protein are enhanced. Treatment with a beta-secretase inhibitor counteracts the increases in the p53 protein levels	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
SH-SY5Y cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)