Literature summary for 3.4.23.46 extracted from

Miyoshi, K.; Ohyagi, Y.; Sakae, N.; Motomura, K.; Ma, L.; Taniwaki, T.; Furuya, H.; Tabira, T.; Kira, J.
Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors (2009), J. Alzheimers Dis., 16, 551-564.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	in presenilin 1 mutants I143T or G384A, acceleration of apoptosis, elevation of caspase 3/7 activity, and significant increases in caspase-4, caspase-8, and caspase-9 activities during apoptosis are observed,. Treatment with a beta-secretase inhibitor significantly attenuates the effects of the presenilin 1 mutants on caspase 3/7 activation and recovers cell viability	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
SH-SY5Y cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)