Application | Comment | Organism |
---|---|---|
pharmacology | design of inhibitor drugs for treatment of Alzheimer disease | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
inhibitor binding site depicted, enhanced affinity by propyloxyphenyl substituent and projection into the S1-S3 pocket of the BACE1 site confirmed, molecular surface model and stereoview indicated | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | design of selective non-peptidic small molecule inhibitors of beta-secretase BACE1, substitution of a thiophene ring for the key pyrrole nucleus in a series of substituted acylguanidines performed | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P56817 | - |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
generation of selective non-peptidic small molecule inhibitors of BACE1, reagents and synthetic route summarized | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | non-peptidic small molecule inhibitors of beta-secretase BACE1 generated, inhibitory activities analyzed by BACE1-FRET assay | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |