Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum lumen | lysine acetylation of maturating BACE1 protein | Homo sapiens | 5788 | - |
endosome | cycling of BACE1 between cell surface and the endosomal system, activation during cellular trafficking | Homo sapiens | 5768 | - |
Golgi lumen | lysine deacetylation, mature BACE1 protein | Homo sapiens | 5796 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P56817 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cell culture | transient acetylation and expression of BACE1 analyzed | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
acetylation of BACE1 on seven lysine residues of the N-terminus shown, substitution of lysine residues shown to block ability of BACE1 to be acetylated in vivo and in vitro, lysine acetylation of BACE1 shown to be required for stabilization and for leaving the endoplasmic reticulum to move ahead into secretory pathway, model of BACE1 transient lysine acetylation/deacetylation presented | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | report on process of reversible lysine acetylation of BACE1 in the endoplasmic reticulum and Golgi lumen, transient lysine acetylation shown to control both translocation along the secretory pathway and molecular stability of BACE1 | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE1 | - |
Homo sapiens |
beta-secretase | - |
Homo sapiens |