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Literature summary for 3.4.23.46 extracted from

  • Costantini, C.; Ko, M.H.; Jonas, M.C.; Puglielli, L.
    A reversible form of lysine acetylation in the ER and Golgi lumen controls the molecular stabilization of BACE1 (2007), Biochem. J., 407, 383-395.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum lumen lysine acetylation of maturating BACE1 protein Homo sapiens 5788
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endosome cycling of BACE1 between cell surface and the endosomal system, activation during cellular trafficking Homo sapiens 5768
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Golgi lumen lysine deacetylation, mature BACE1 protein Homo sapiens 5796
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Organism

Organism UniProt Comment Textmining
Homo sapiens P56817
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Source Tissue

Source Tissue Comment Organism Textmining
cell culture transient acetylation and expression of BACE1 analyzed Homo sapiens
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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acetylation of BACE1 on seven lysine residues of the N-terminus shown, substitution of lysine residues shown to block ability of BACE1 to be acetylated in vivo and in vitro, lysine acetylation of BACE1 shown to be required for stabilization and for leaving the endoplasmic reticulum to move ahead into secretory pathway, model of BACE1 transient lysine acetylation/deacetylation presented Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information report on process of reversible lysine acetylation of BACE1 in the endoplasmic reticulum and Golgi lumen, transient lysine acetylation shown to control both translocation along the secretory pathway and molecular stability of BACE1 Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
BACE1
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Homo sapiens
beta-secretase
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Homo sapiens