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Literature summary for 3.4.23.46 extracted from

  • Angeletti, B.; Waldron, K.J.; Freeman, K.B.; Bawagan, H.; Hussain, I.; Miller, C.C.; Lau, K.F.; Tennant, M.E.; Dennison, C.; Robinson, N.J.; Dingwall, C.
    BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper (2005), J. Biol. Chem., 280, 17930-17937.
    View publication on PubMed
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Metals/Ions

Metals/Ions Comment Organism Structure
Cu BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Rattus norvegicus first step in generation of the Abeta peptide is the cleavage of amyloid precursor protein by BACE1. BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper. BACE1 provides a link between metal homoeostasis and oxidative stress in Alzheimer disease ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O first step in generation of the Abeta peptide is the cleavage of amyloid precursor protein by BACE1. BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper. BACE1 provides a link between metal homoeostasis and oxidative stress in Alzheimer disease Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
BACE1
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 Rattus norvegicus