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Literature summary for 3.4.23.46 extracted from

  • Yan, R.; Han, P.; Miao, H.; Greengard, P.; Xu, H.
    The transmembrane domain of the Alzheimer's b-secretase (BACE1) determines its late Golgi localization and access to beta-amyloid precursor protein (APP) substrate (2001), J. Biol. Chem., 276, 36788-36796.
    View publication on PubMed
Search for more literature for 3.4.23.46

Protein Variants

Protein Variants Comment Organism
additional information various fragments fused to green flourescence protein Mus musculus
additional information various fragments fused to green flourescence protein Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum BACE1, minor presence Mus musculus 5783
-
endoplasmic reticulum BACE1, minor presence Homo sapiens 5783
-
endosome BACE1, minor presence Mus musculus 5768
-
endosome BACE1, minor presence Homo sapiens 5768
-
Golgi apparatus largely late Golgi, BACE1 Mus musculus 5794
-
Golgi apparatus largely late Golgi, BACE1 Homo sapiens 5794
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein mechanism for enzyme regulation Mus musculus
a
broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein mechanism for enzyme regulation Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O
-
 Homo sapiens ?
-
 ?
Swedish variant of amyloid precursor protein + H2O
-
 Homo sapiens ?
-
 ?