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Literature summary for 3.4.23.43 extracted from

  • Tomich, M.; Fine, D.H.; Figurski, D.H.
    The TadV protein of Actinobacillus actinomycetemcomitans is a novel aspartic acid prepilin peptidase required for maturation of the Flp1 pilin and TadE and TadF pseudopilins (2006), J. Bacteriol., 188, 6899-6914.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene tadV, DNA and amino acid sequence determination and analysis, functional expression of wild-type enzyme in Escherichia coli strain BL21(DE3) Aggregatibacter actinomycetemcomitans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Flp1 prepilin + H2O Aggregatibacter actinomycetemcomitans the enzyme is required for maturation of the Flp1 pilin and TadE and TadF pseudopilins which are essential for adhesion of the bacterium to surfaces and formation of strong biofilms Flp1 pilin + Flp1 prepilin leader peptide
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 ?
TadE prepseudopilin + H2O Aggregatibacter actinomycetemcomitans the enzyme is required for maturation of the Flp1 pilin and TadE and TadF pilin-like proteins which are essential for adhesion of the bacterium to surfaces and formation of strong biofilms TadE pseudopilin + TadE prepseudopilin leader peptide
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 ?
TadF prepseudopilin + H2O Aggregatibacter actinomycetemcomitans the enzyme is required for maturation of the Flp1 pilin and TadE and TadF pilin-like proteins which are essential for adhesion of the bacterium to surfaces and formation of strong biofilms TadF pseudopilin + TadF prepseudopilin leader peptide
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 ?

Organism

Organism UniProt Comment Textmining
Aggregatibacter actinomycetemcomitans
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 gene tadV of the tad locus
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Purification (Commentary)

Purification (Comment) Organism
native TadV partially from Actinobacillus actinomycetemcomitans strains Aggregatibacter actinomycetemcomitans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Flp1 prepilin + H2O
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 Aggregatibacter actinomycetemcomitans Flp1 pilin + Flp1 prepilin leader peptide
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 ?
Flp1 prepilin + H2O the enzyme is required for maturation of the Flp1 pilin and TadE and TadF pseudopilins which are essential for adhesion of the bacterium to surfaces and formation of strong biofilms Aggregatibacter actinomycetemcomitans Flp1 pilin + Flp1 prepilin leader peptide
-
 ?
additional information activity rate with different recombinant mutants of Flp1, TadE, and TadF constructed by site-directed mutagenesis and expressed in Escherichia coli, overview Aggregatibacter actinomycetemcomitans ?
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 ?
TadE prepseudopilin + H2O
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 Aggregatibacter actinomycetemcomitans TadE pseudopilin + TadE prepseudopilin leader peptide
-
 ?
TadE prepseudopilin + H2O the enzyme is required for maturation of the Flp1 pilin and TadE and TadF pilin-like proteins which are essential for adhesion of the bacterium to surfaces and formation of strong biofilms Aggregatibacter actinomycetemcomitans TadE pseudopilin + TadE prepseudopilin leader peptide
-
 ?
TadF prepseudopilin + H2O
-
 Aggregatibacter actinomycetemcomitans TadF pseudopilin + TadF prepseudopilin leader peptide
-
 ?
TadF prepseudopilin + H2O the enzyme is required for maturation of the Flp1 pilin and TadE and TadF pilin-like proteins which are essential for adhesion of the bacterium to surfaces and formation of strong biofilms Aggregatibacter actinomycetemcomitans TadF pseudopilin + TadF prepseudopilin leader peptide
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 ?

Synonyms

Synonyms Comment Organism
TadV protein
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 Aggregatibacter actinomycetemcomitans