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Literature summary for 3.4.23.43 extracted from
- The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases (2000), J. Biol. Chem., 275, 1502-1510.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Vibrio cholerae serotype O1 |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C51A | activity identical to wild-type | Vibrio cholerae serotype O1 |
| C73A | activity identical to wild-type | Vibrio cholerae serotype O1 |
| C76A | activity identical to wild-type | Vibrio cholerae serotype O1 |
| D125A | no peptidase activity | Vibrio cholerae serotype O1 |
| D125E | partial peptidase activity | Vibrio cholerae serotype O1 |
| D125N | no peptidase activity | Vibrio cholerae serotype O1 |
| D183N | activity identical to wild-type | Vibrio cholerae serotype O1 |
| D189E | partial peptidase activity | Vibrio cholerae serotype O1 |
| D189N | no peptidase activity | Vibrio cholerae serotype O1 |
| D198A | no peptidase activity | Vibrio cholerae serotype O1 |
| E88A | activity identical to wild-type | Vibrio cholerae serotype O1 |
| K191A | activity identical to wild-type | Vibrio cholerae serotype O1 |
| S172A | activity identical to wild-type | Vibrio cholerae serotype O1 |
| S18A | activity identical to wild-type | Vibrio cholerae serotype O1 |
| S46A | activity identical to wild-type | Vibrio cholerae serotype O1 |
| S65A | activity identical to wild-type | Vibrio cholerae serotype O1 |
| S81L | activity identical to wild-type | Vibrio cholerae serotype O1 |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride/glycinamide | inhibitor for acid proteases | Vibrio cholerae serotype O1 |  |
| additional information | no inhibition by inhibitors of cysteine proteases, serine proteases, metallopeptidases, aminopeptidases, aspartic proteases | Vibrio cholerae serotype O1 |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Vibrio cholerae serotype O1 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| TcpA + H2O | prepilin-containing membrane preparation | Vibrio cholerae serotype O1 | ? | - |
? | |
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Release 2023.1 (January 2023)
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