Literature summary for 3.4.23.40 extracted from

Frazao, C.; Bento, I.; Costa, J.; Soares, C.M.; Verissimo, P.; Faro, C.; Pires, E.; Cooper, J.; Carrondo, M.A.
Crystal structure of cardosin A, a glycosylated and Arg-Gly-Asp-containing aspartic proteinase from the flowers of Cynara cardunculus L. (1999), J. Biol. Chem., 274, 27694-27701.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
to 1.72 A resoultion. Structure includes two molecules, built up by two glycosylated peptide chains of 31 and 15 kDa. The glycosyl content is described by 19 sugar rings attached to residues Asn67 and Asn257 localized on the molecular surface away from the conserved active site. A hydrogen bond between Gln126 and Manbeta4 renders the monosaccharide oxygen O2 sterically inaccessible to accept a xylosyl residue, explaining a hitherto unknown type of plant glycan. The Arg-Gly-Asp sequence, involved in recognition of a putative cardosin A receptor, is found in a loop between two beta-strands on the molecular surface opposite the active site cleft	Cynara cardunculus

Crystallization (Comment)

Organism

to 1.72 A resoultion. Structure includes two molecules, built up by two glycosylated peptide chains of 31 and 15 kDa. The glycosyl content is described by 19 sugar rings attached to residues Asn67 and Asn257 localized on the molecular surface away from the conserved active site. A hydrogen bond between Gln126 and Manbeta4 renders the monosaccharide oxygen O2 sterically inaccessible to accept a xylosyl residue, explaining a hitherto unknown type of plant glycan. The Arg-Gly-Asp sequence, involved in recognition of a putative cardosin A receptor, is found in a loop between two beta-strands on the molecular surface opposite the active site cleft

Cynara cardunculus

Organism

Organism	UniProt	Comment	Textmining
Cynara cardunculus	Q9XFX3	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	structure contains two glycosylated peptide chains of 31 and 15 kDa. 19 sugar rings are attached to residues Asn67 and Asn257 localized on the molecular surface away from the conserved active site	Cynara cardunculus

Source Tissue

Source Tissue	Comment	Organism	Textmining

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Release 2023.1 (January 2023)