Literature summary for 3.4.23.39 extracted from

Kim, Y.M.; Lee, M.H.; Piao, T.G.; Lee, J.W.; Kim, J.H.; Lee, S.; Choi, K.M.; Jiang, J.H.; Kim, T.U.; Park, H.
Prodomain processing of recombinant plasmepsin II and IV, the aspartic proteases of Plasmodium falciparum, is auto- and trans-catalytic (2006), J. Biochem., 139, 189-195.

Search for more literature for 3.4.23.39

Cloned(Commentary)

Cloned (Comment)	Organism
wild-type and mutant enzymes	Plasmodium falciparum

Protein Variants

Protein Variants	Comment	Organism
D158A	active-site mutant of both plasmepsin II and IV shows neither autocatalytic processing nor proteolytic activities	Plasmodium falciparum
D338A	active-site mutant of both plasmepsin II and IV shows neither autocatalytic processing nor proteolytic activities	Plasmodium falciparum
additional information	active-site mutants of both plasmepsin II and IV showed neither autocatalytic processing nor proteolytic activities. The mutants of both plasmepsins are efficiently processed upon incubation with their respective wild type proteins	Plasmodium falciparum
proteolytic modification	prodomain processing of plasmepsin II and plasmepsin IV occurs via an intra- and inter-molecular autocatalytic event as well as via a transcatalytic event between them	Plasmodium falciparum

Inhibitors

Inhibitors	Comment	Organism	Structure
N-acetyl-L-leucyl-L-leucyl-norleucinal	-	Plasmodium falciparum
pepstatin A	-	Plasmodium falciparum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
food vacuole	-	Plasmodium falciparum	20020	-

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
proteolytic modification	the processing of PM II and IV occurs via an intra- and inter-molecular autocatalytic event as well as via a transcatalytic event between them	Plasmodium falciparum

Purification (Commentary)

Purification (Comment)	Organism
-	Plasmodium falciparum

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Hemoglobin + H2O	-	Plasmodium falciparum	?	-	?

Synonyms

Synonyms	Comment	Organism
PM II	-	Plasmodium falciparum

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)