Cloned (Comment) | Organism |
---|---|
- |
Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N'1-[(E)-(2,3-dihydroxyphenyl)methylidene]-N'3-[(Z)-(2,3-dihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide | - |
Plasmodium falciparum | |
Ro17-7109 | - |
Plasmodium falciparum | |
Ro40-4388 | - |
Plasmodium falciparum | |
Ro40-5576 | - |
Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C | Plasmodium falciparum | |
0.025 | - |
Lys-Glu-Phe-Ile-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | plasmepsin II is produced as a precursor. The propart region, about 120 residues, is more than twice as long as those of archetypal zymogens | Plasmodium falciparum |
Purification (Comment) | Organism |
---|---|
proplasmepsin | Plasmodium falciparum |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
trophozoite | the proplasmepsin II gene is not transcribed until the later trophozoite stage of parasite growth | Plasmodium falciparum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe + H2O | - |
Plasmodium falciparum | Leu-Glu-Arg-Ile-Phe + Phe(NO2)-Ser-Phe | - |
? | |
Lys-Glu-Phe-Ile-Phe-Phe(NO2)-Ala-Leu-Lys + H2O | - |
Plasmodium falciparum | Lys-Glu-Phe-Ile-Phe + Phe(NO2)-Ala-Leu-Lys | - |
? | |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys + H2O | - |
Plasmodium falciparum | Lys-Glu-Phe-Val-Phe + Phe(NO2)-Ala-Leu-Lys | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
9.05 | - |
Lys-Glu-Phe-Val-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C | Plasmodium falciparum | |
15.2 | - |
Lys-Glu-Phe-Ile-Phe-Phe(NO2)-Ala-Leu-Lys | pH 4.4, 37°C | Plasmodium falciparum |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
3.5 | 6 | pH 3.5: about 65% of maximal activity, pH 6.0: about 30% of maximal activity, hydrolysis of Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe | Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | the Ki-value for Ro17-7109 is above 0.015 mM | Plasmodium falciparum | |
0.00025 | - |
Ro40-5576 | pH 4.4, 37°C | Plasmodium falciparum | |
0.0007 | - |
Ro40-4388 | pH 4.4, 37°C | Plasmodium falciparum | |
0.004 | - |
N'1-[(E)-(2,3-dihydroxyphenyl)methylidene]-N'3-[(Z)-(2,3-dihydroxyphenyl)methylidene]benzene-1,3-dicarbohydrazide | pH 4.4, 37°C | Plasmodium falciparum |