Cloned (Comment) | Organism |
---|---|
engineering a plasmepsin II with the active site surface of plasmepsin I and expression in Escherichia coli | Plasmodium falciparum |
Protein Variants | Comment | Organism |
---|---|---|
additional information | engineering a plasmepsin II with the active site surface of plasmepsin I largely maintains the plasmepsin II substrate and inhibitor specificity | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
pepstatin | - |
Plasmodium falciparum | |
SC-50083 | IC50: 0.0003467 mM | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000489 | - |
4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-(gamma-aminobutyryl)-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid | pH 5.0, 37°C | Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Hemoglobin + H2O | Plasmodium falciparum | enzyme is involved in initial steps of Plasmodium hemoglobin degradation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-(gamma-aminobutyryl)-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid + H2O | - |
Plasmodium falciparum | ? | - |
? | |
Hemoglobin + H2O | enzyme is involved in initial steps of Plasmodium hemoglobin degradation | Plasmodium falciparum | ? | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.31 | - |
4-[[4'-(dimethylamino)phenyl]azo]-benzoyl-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-(gamma-aminobutyryl)-5-[(2'-aminoethyl)-amino]naphthalenesulfonic acid | pH 5.0, 37°C | Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000000037 | - |
pepstatin | pH 5.0, 37°C | Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0003467 | - |
IC50: 0.0003467 mM | Plasmodium falciparum | SC-50083 |