Any feedback?
Literature summary for 3.4.23.38 extracted from
- Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring (2009), ChemMedChem, 4, 1317-1326.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-[2-hydroxy-3-(1,2,3,4,5,6,7,8-octahydrophenanthren-9-yloxy)propyl]-4-(3-methoxyphenyl)piperazin-1-ium | - |
Plasmodium falciparum |  |
| 3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,5a,6,11,11a-octahydrotetracen-1-yl 3,4-di-O-acetyl-2,6-dideoxyhexopyranoside | - |
Plasmodium falciparum | |
| 3-[3-(4-chlorophenyl)-3-hydroxy-3-phenylpropyl]-3-azoniabicyclo[4.2.1]nonane | - |
Plasmodium falciparum | |
| 5-[bis[(benzyloxy)carbonyl]amino]-6-[[1-hydrazinyl-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-6-oxohexan-1-aminium | - |
Plasmodium falciparum | |
| N,N-dibutyl-3-(1,4-dihydronaphthalen-1-yl)-3-hydroxybutan-1-aminium | - |
Plasmodium falciparum | |
| N-butyl-N-[2-[6-chloro-3-(3,4-dichlorophenyl)naphthalen-1-yl]-2-hydroxyethyl]butan-1-aminium | - |
Plasmodium falciparum | |
| N-hexyl-N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]hexan-1-aminium | - |
Plasmodium falciparum | |
| N-hexyl-N-[2-hydroxy-2-(phenanthren-9-yl)ethyl]hexan-1-aminium | - |
Plasmodium falciparum | |
| N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]-4-methyl-N-(4-methylpentyl)pentan-1-aminium | - |
Plasmodium falciparum | |
| N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]-N-pentylpentan-1-aminium | - |
Plasmodium falciparum | |
| N-[3-(2,7-dichloro-9H-fluoren-4-yl)-3-hydroxypropyl]-N-pentylpentan-1-aminium | - |
Plasmodium falciparum | |
| N-[3-(9H-fluoren-2-yl)-3-hydroxypropyl]-N-pentylpentan-1-aminium | - |
Plasmodium falciparum | |
| N-[3-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]-3-hydroxypropyl]-N-pentylpentan-1-aminium | - |
Plasmodium falciparum | |
| pepstatin | - |
Plasmodium falciparum | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Plasmodium falciparum | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| plasmepsin I | - |
Plasmodium falciparum |
| PM I | - |
Plasmodium falciparum |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
assay at | Plasmodium falciparum |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000001 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | pepstatin | |
| 0.002 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-butyl-N-[2-[6-chloro-3-(3,4-dichlorophenyl)naphthalen-1-yl]-2-hydroxyethyl]butan-1-aminium | |
| 0.003 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-[3-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]-3-hydroxypropyl]-N-pentylpentan-1-aminium | |
| 0.003 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]-4-methyl-N-(4-methylpentyl)pentan-1-aminium | |
| 0.004 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-hexyl-N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]hexan-1-aminium | |
| 0.022 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | 3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,5a,6,11,11a-octahydrotetracen-1-yl 3,4-di-O-acetyl-2,6-dideoxyhexopyranoside | |
| 0.022 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | 1-[2-hydroxy-3-(1,2,3,4,5,6,7,8-octahydrophenanthren-9-yloxy)propyl]-4-(3-methoxyphenyl)piperazin-1-ium | |
| 0.023 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-[2-hydroxy-2-(1,2,3,4-tetrahydrophenanthren-9-yl)ethyl]-N-pentylpentan-1-aminium | |
| 0.023 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-hexyl-N-[2-hydroxy-2-(phenanthren-9-yl)ethyl]hexan-1-aminium | |
| 0.024 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N,N-dibutyl-3-(1,4-dihydronaphthalen-1-yl)-3-hydroxybutan-1-aminium | |
| 0.028 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | 3-[3-(4-chlorophenyl)-3-hydroxy-3-phenylpropyl]-3-azoniabicyclo[4.2.1]nonane | |
| 0.037 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | 5-[bis[(benzyloxy)carbonyl]amino]-6-[[1-hydrazinyl-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-6-oxohexan-1-aminium | |
| 0.041 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-[3-(2,7-dichloro-9H-fluoren-4-yl)-3-hydroxypropyl]-N-pentylpentan-1-aminium | |
| 0.071 | - |
pH 5.0, temperature not specified in the publication | Plasmodium falciparum | N-[3-(9H-fluoren-2-yl)-3-hydroxypropyl]-N-pentylpentan-1-aminium | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
