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Literature summary for 3.4.23.38 extracted from

  • Goldberg, D.E.; Slater, A.F.G.; Beavis, R.; Chait, B.; Cerami, A.; Henderson, G.B.
    Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease (1991), J. Exp. Med., 173, 961-969.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.23.38

Inhibitors

Inhibitors Comment Organism Structure
(2R,3R,4R,5R)-N1,N6-bis[(1S,2R)-2-hydroxy-1-indanyl]-2,5-bis[(2E)-3-(4-fluorophenyl)-2-propenyloxy]-3,4-dihydroxyhexane-1,6-diamide
-
 Plasmodium falciparum
(2R,3R,4R,5R)-N1,N6-bis[(1S,2R)-2-hydroxy-1-indanyl]-2,5-bis[(2E)-pent-2-en-4-ynyl]-3,4-dihydroxyhexane-1,6-diamide
-
 Plasmodium falciparum
pepstatin IC50: about 5 nM Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 x * 40000, SDS-PAGE Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Plasmodium falciparum

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.04
-
-
 Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hemoglobin alpha-chain + H2O cleavage of the Phe33-/-Leu34- bond Plasmodium falciparum ?
-
 ?

Subunits

Subunits Comment Organism
? x * 40000, SDS-PAGE Plasmodium falciparum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
-
 Plasmodium falciparum

pH Range

pH Minimum pH Maximum Comment Organism
4 6.5 pH 4.0: about 20% of maximal activity, pH 4.5: about 90% of maximal activity, pH 6.0: about 60% of maximal activity, pH 6.5: about 30% of maximal activity Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000025
-
 (2R,3R,4R,5R)-N1,N6-bis[(1S,2R)-2-hydroxy-1-indanyl]-2,5-bis[(2E)-3-(4-fluorophenyl)-2-propenyloxy]-3,4-dihydroxyhexane-1,6-diamide
-
 Plasmodium falciparum
0.000037
-
 (2R,3R,4R,5R)-N1,N6-bis[(1S,2R)-2-hydroxy-1-indanyl]-2,5-bis[(2E)-pent-2-en-4-ynyl]-3,4-dihydroxyhexane-1,6-diamide
-
 Plasmodium falciparum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000005
-
 IC50: about 5 nM Plasmodium falciparum pepstatin